Next Article in Journal
Deposition of Metal-Organic Frameworks by Liquid-Phase Epitaxy: The Influence of Substrate Functional Group Density on Film Orientation
Next Article in Special Issue
In Vivo Toxicity of Intravenously Administered Silica and Silicon Nanoparticles
Previous Article in Journal
Adaptive Holography in Liquid Crystal Light-Valves
Article Menu

Export Article

Open AccessArticle
Materials 2012, 5(9), 1560-1580;

Early Combination of Material Characteristics and Toxicology Is Useful in the Design of Low Toxicity Carbon Nanofiber

Statoil ASA, Stavanger NO-4035, Norway
Elkem Carbon AS, PO Box 8040 Vaagsbygd, Kristiansand NO-4675, Norway
Department of Environmental Immunology, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, Oslo NO-0403, Norway
Department of Synthesis and Properties, SINTEF Materials and Chemistry, Trondheim NO-7465, Norway
Department of Neuroscience, Faculty of Medicine, The Norwegian University of Science and Technology, MTFS, Trondheim NO-7489, Norway
Author to whom correspondence should be addressed.
Received: 20 June 2012 / Revised: 20 August 2012 / Accepted: 27 August 2012 / Published: 3 September 2012
(This article belongs to the Special Issue Nanotoxicology)
Full-Text   |   PDF [1638 KB, uploaded 3 September 2012]   |  


This paper describes an approach for the early combination of material characterization and toxicology testing in order to design carbon nanofiber (CNF) with low toxicity. The aim was to investigate how the adjustment of production parameters and purification procedures can result in a CNF product with low toxicity. Different CNF batches from a pilot plant were characterized with respect to physical properties (chemical composition, specific surface area, morphology, surface chemistry) as well as toxicity by in vitro and in vivo tests. A description of a test battery for both material characterization and toxicity is given. The results illustrate how the adjustment of production parameters and purification, thermal treatment in particular, influence the material characterization as well as the outcome of the toxic tests. The combination of the tests early during product development is a useful and efficient approach when aiming at designing CNF with low toxicity. Early quality and safety characterization, preferably in an iterative process, is expected to be efficient and promising for this purpose. The toxicity tests applied are preliminary tests of low cost and rapid execution. For further studies, effects such as lung inflammation, fibrosis and respiratory cancer are recommended for the more in-depth studies of the mature CNF product. View Full-Text
Keywords: carbon nanofiber; toxicity; characterization carbon nanofiber; toxicity; characterization

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Jensen, E.K.; Larsen, S.Y.; Nygaard, U.C.; Marioara, C.D.; Syversen, T. Early Combination of Material Characteristics and Toxicology Is Useful in the Design of Low Toxicity Carbon Nanofiber. Materials 2012, 5, 1560-1580.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top