Release of Ciprofloxacin-HCl and Dexamethasone Phosphate by Hyaluronic Acid Containing Silicone Polymers
Abstract
:1. Introduction
2. Results and Discussion
2.1. Ciprofloxacin-HCl Release from HA Materials
Modification | None (control) | HA 35 | HA 132 | |||
---|---|---|---|---|---|---|
Material | mean | SD | mean | SD | mean | SD |
pHEMA | 328 | 13 | 337 | 33 | 361 | 5 |
pHEMA TRIS | 99 | 12 | 85 | 0.4 | 133 | 22 |
DMAA TRIS | 48 | 3 | 68 | 5 | 86 | 22 |
2.2. Dexamethasone Release from HA Materials
Modification | None (control) | HA 35 | HA 132 | |||
---|---|---|---|---|---|---|
Material | mean | SD | Mean | SD | mean | SD |
pHEMA | 109 | 15 | 53 | 5 | 57 | 6 |
pHEMA TRIS | 12 | 1 | 13 | 0.7 | 13 | 0.9 |
DMAA TRIS | 13 | 0.6 | 23 | 2 | 21 | 1 |
3. Experimental Section
3.1. Solution Preparation
3.2. Model Materials
3.3. Drug Loading
3.4. Release Kinetics
3.5. Analysis
3.6. Photographs
4. Conclusions
Acknowledgments
References
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Nguyen, D.; Hui, A.; Weeks, A.; Heynen, M.; Joyce, E.; Sheardown, H.; Jones, L. Release of Ciprofloxacin-HCl and Dexamethasone Phosphate by Hyaluronic Acid Containing Silicone Polymers. Materials 2012, 5, 684-698. https://doi.org/10.3390/ma5040684
Nguyen D, Hui A, Weeks A, Heynen M, Joyce E, Sheardown H, Jones L. Release of Ciprofloxacin-HCl and Dexamethasone Phosphate by Hyaluronic Acid Containing Silicone Polymers. Materials. 2012; 5(4):684-698. https://doi.org/10.3390/ma5040684
Chicago/Turabian StyleNguyen, Darrene, Alex Hui, Andrea Weeks, Miriam Heynen, Elizabeth Joyce, Heather Sheardown, and Lyndon Jones. 2012. "Release of Ciprofloxacin-HCl and Dexamethasone Phosphate by Hyaluronic Acid Containing Silicone Polymers" Materials 5, no. 4: 684-698. https://doi.org/10.3390/ma5040684