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Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury

1
Key Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University, Hangzhou 310027, China
2
Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
3
Zeo-Innov Medical Technology Corporation, Hangzhou 310023, China
*
Author to whom correspondence should be addressed.
Materials 2012, 5(12), 2586-2596; https://doi.org/10.3390/ma5122586
Received: 15 October 2012 / Revised: 26 November 2012 / Accepted: 27 November 2012 / Published: 3 December 2012
(This article belongs to the Special Issue Advances in Mesoporous Materials)
Quikclot has been used many years for treating external hemorrhage in the battle field. In this study, the hemostatic performance of NZG-JY (natural zeolite granules from Jinyun, China) was evaluated and compared with Quikclot in a lethal rabbit model of complex groin injury. Fifty-six anesthetized rabbits were randomized to three different groups: (1) NZG-JY (n = 19); (2) Quikclot (n = 19); and (3) medical gauze (n = 18). Survival was recorded three hours after the application of the hemostatic agents. The wound healing properties of the survived animals (n = 4 for each group) were observed a week later. The clotting efficiency is 100% for the animals in the NZG-JY and the Quikclot group, while only 5.6% in the gauze group. The mortality in the NZG-JY group (21.0%) is significantly less than that in the Quikclot group (52.6%) and the gauze group (66.7%). A good healing property was achieved in all animals that survived in the NZG-JY group, while three quarters of the animals in the Quikclot group had serious necrotic tissue. NZG-JY significantly decreases the mortality in a lethal rabbit model of complex groin injury and demonstrates good healing properties. View Full-Text
Keywords: natural zeolite; hemostatic efficiency; mortality; wound healing; groin injury natural zeolite; hemostatic efficiency; mortality; wound healing; groin injury
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Li, Y.; Li, H.; Xiao, L.; Zhou, L.; Shentu, J.; Zhang, X.; Fan, J. Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury. Materials 2012, 5, 2586-2596.

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