Next Article in Journal
A Preliminary Study on the Effect of Macro Cavities Formation on Properties of Carbon Nanotube Bucky-Paper Composites
Previous Article in Journal
Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering
Open AccessArticle

Crosslinked Graft Copolymer of Methacrylic Acid and Gelatin as a Novel Hydrogel with pH-Responsiveness Properties

1
Department of Chemistry, Science Faculty, Islamic Azad University, Arak Branch, 38156 Arak, Iran
2
Department of Chemical Engineering, Engineer Faculty, Islamic Azad University, Arak Branch, 38156 Arak, Iran
*
Author to whom correspondence should be addressed.
Materials 2011, 4(3), 543-552; https://doi.org/10.3390/ma4030543
Received: 15 January 2011 / Revised: 20 February 2011 / Accepted: 24 February 2011 / Published: 2 March 2011
(This article belongs to the Special Issue Recent Advances in Stimuli-Responsive Materials)
In this paper, a novel gelatin-based hydrogel was synthesized through crosslinking graft copolymerization of methacrylic acid (MAA) onto gelatin, using ammonium persulfate (APS) as a free radical initiator in the presence of methylenebisacrylamide (MBA) as a crosslinker. A proposed mechanism for hydrogel formation was suggested and the structure of the product was established using FTIR spectroscopy and gravimetric analysis of the products. Moreover, morphology of the samples was examined by scanning electron microscopy (SEM) and thermogravimetric analysis (TGA/DTG). The effect of reaction variables such as concentration of APS and MBA were systematically optimized to achieve a hydrogel with swelling capacity as high as possible. The gelatin-g-PMAA hydrogel exhibited a pH-responsiveness character so that a swelling-deswelling pulsatile behavior was recorded at pHs 2 and 8. This on-off switching behavior makes the hydrogel as a good candidate for controlled delivery of bioactive agents. View Full-Text
Keywords: gelatin; methacrylic acid; graft copolymers gelatin; methacrylic acid; graft copolymers
Show Figures

Figure 1

MDPI and ACS Style

Sadeghi, M.; Heidari, B. Crosslinked Graft Copolymer of Methacrylic Acid and Gelatin as a Novel Hydrogel with pH-Responsiveness Properties. Materials 2011, 4, 543-552.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop