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Review

Novel Bioactive Titanate Layers Formed on Ti Metal and Its Alloys by Chemical Treatments

by
Tadashi Kokubo
* and
Seiji Yamaguchi
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan
*
Author to whom correspondence should be addressed.
Materials 2010, 3(1), 48-63; https://doi.org/10.3390/ma3010048
Submission received: 30 November 2009 / Revised: 16 December 2009 / Accepted: 22 December 2009 / Published: 25 December 2009
(This article belongs to the Special Issue Ceramics for Healthcare)
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Abstract

Sodium titanate formed on Ti metal by NaOH and heat treatments induces apatite formation on its surface in a body environment and bonds to living bone. These treatments have been applied to porous Ti metal in artificial hip joints, and have been used clinically in Japan since 2007. Calcium titanate formed on Ti-15Zr-4Nb-4Ta alloy by NaOH, CaCl2, heat, and water treatments induces apatite formation on its surface in a body environment. Titanium oxide formed on porous Ti metal by NaOH, HCl, and heat treatments exhibits osteoinductivity as well as osteoconductivity. This is now under clinical tests for application to a spinal fusion device.
Keywords: bioactive; titanate; osteoinduction; osteoconduction; Ti metal; Ti-based alloy; artificial joint; spinal fusion device; apatite bioactive; titanate; osteoinduction; osteoconduction; Ti metal; Ti-based alloy; artificial joint; spinal fusion device; apatite

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MDPI and ACS Style

Kokubo, T.; Yamaguchi, S. Novel Bioactive Titanate Layers Formed on Ti Metal and Its Alloys by Chemical Treatments. Materials 2010, 3, 48-63. https://doi.org/10.3390/ma3010048

AMA Style

Kokubo T, Yamaguchi S. Novel Bioactive Titanate Layers Formed on Ti Metal and Its Alloys by Chemical Treatments. Materials. 2010; 3(1):48-63. https://doi.org/10.3390/ma3010048

Chicago/Turabian Style

Kokubo, Tadashi, and Seiji Yamaguchi. 2010. "Novel Bioactive Titanate Layers Formed on Ti Metal and Its Alloys by Chemical Treatments" Materials 3, no. 1: 48-63. https://doi.org/10.3390/ma3010048

APA Style

Kokubo, T., & Yamaguchi, S. (2010). Novel Bioactive Titanate Layers Formed on Ti Metal and Its Alloys by Chemical Treatments. Materials, 3(1), 48-63. https://doi.org/10.3390/ma3010048

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