Additive Manufacturing of Biomaterials—Design Principles and Their Implementation
Abstract
:1. Introduction
2. Geometrical Design of Lattices
2.1. Library-Based Design
2.1.1. Beam-Based Unit Cells
2.1.2. Surface-Based Unit Cells
2.1.3. Disordered and Random Network Designs
2.2. Topology Optimisation Designs
2.3. Bio-Inspired Design
2.4. Meta-Biomaterials
3. AM of Biomedical Metals and Alloys
3.1. Biodegradable Metals
3.2. Shape-Memory Alloys
3.3. In Situ Alloying and Composites
4. AM of Biomedical Polymers
4.1. Hydrogels
4.2. Natural Polymers (Hydrogel)
4.2.1. Collagen
4.2.2. Gelatine
4.2.3. Alginate
4.3. Synthetic Polymers
4.3.1. Synthetic Hydrogels
4.3.2. Polylactic Acid (PLA)
4.3.3. Polycaprolactone (PCL)
4.3.4. Poly(lactic-co-glycolic) Acid (PLGA)
4.3.5. Proprietary Polymers
4.4. Composites
4.4.1. Particle-Reinforced Polymer Composites
4.4.2. Fibre-Reinforced Polymer Composites
4.4.3. Nanocomposites
5. AM of Biomedical Ceramics
5.1. Classification of Ceramics
5.2. Properties of Ceramics
5.3. Manufacturing Methods for Ceramics
- Casting/solidification methods: in this category, the liquid and solid states of the starting material change, and this is accompanied by some volumetric changes in most cases.
- Deformation methods: in this category, ceramic structures are formed through a plastic deformation process.
- Machining and material removal methods: an abrasive process is applied to remove the material from a ceramic block.
- Joining methods: in this category of methods, different ceramic bits and pieces are combined using various joining techniques.
- Solid free-form fabrication methods: this category of methods includes various AM methods for the fabrication of ceramics.
5.3.1. Powder-Based 3D Printing (P-3DP)
Binder Jetting
Selective Laser Sintering (SLS)
5.3.2. Stereolithography (SLA)
5.3.3. Extrusion-Based 3D Printing: Robocasting, Direct Ink Writing (DIW), and FDM
5.3.4. Negative AM Techniques
5.4. Biomedical Applications of Ceramics
6. Conclusions and Future Research Directions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Techniques and Materials | Pros | Cons | Biomedical Application | ||
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Material Deposition | Material Extrusion (FDM)
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Directed Energy Deposition (DED)
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Material Jetting (Polyjet)
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Powder-based | PBF (SLS, SLM, DMLS, EBM)
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Binder Jetting
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Liquid-based | SLA
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DLP
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Design Strategy | Method | Geometry/Mechanism Example | Unique Feature | Caution in 3D Printability |
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Library-based | Ordered unit cells |
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Disordered unit cells |
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Topology optimisation | Analytical mathematical models and computational approaches to design and obtain optimised microstructures |
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Bio-inspired design | Bio-inspired designs |
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Image-based |
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Meta-biomaterials | Designer material or mechanical metamaterial |
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Kinematic or compliant mechanism-based designs |
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Mirzaali, M.J.; Moosabeiki, V.; Rajaai, S.M.; Zhou, J.; Zadpoor, A.A. Additive Manufacturing of Biomaterials—Design Principles and Their Implementation. Materials 2022, 15, 5457. https://doi.org/10.3390/ma15155457
Mirzaali MJ, Moosabeiki V, Rajaai SM, Zhou J, Zadpoor AA. Additive Manufacturing of Biomaterials—Design Principles and Their Implementation. Materials. 2022; 15(15):5457. https://doi.org/10.3390/ma15155457
Chicago/Turabian StyleMirzaali, Mohammad J., Vahid Moosabeiki, Seyed Mohammad Rajaai, Jie Zhou, and Amir A. Zadpoor. 2022. "Additive Manufacturing of Biomaterials—Design Principles and Their Implementation" Materials 15, no. 15: 5457. https://doi.org/10.3390/ma15155457