Next Article in Journal
Anatase Titanium Dioxide Imparts Photoluminescent Properties to PA2200 Commercial 3D Printing Material to Generate Complex Optical Imaging Phantoms
Previous Article in Journal
Random Forest Approach in Modeling the Flow Stress of 304 Stainless Steel during Deformation at 700 °C–900 °C
Previous Article in Special Issue
Calcium Phosphate Modified with Silicon vs. Bovine Hydroxyapatite for Alveolar Ridge Preservation: Densitometric Evaluation, Morphological Changes and Histomorphometric Study
Open AccessArticle

Silane-Coating Strategy for Titanium Functionalization Does Not Impair Osteogenesis In Vivo

1
Health Science Center, Unigranrio University, Rio de Janeiro 25071-202, Brazil
2
Biotechnology Department, Universidade Federal Fluminense, Niteroi 24070-035, Brazil
3
Graduate Program, School of Dentistry, Universidade Federal Fluminense, Niteroi 24020-140, Brazil
4
Private Practice, 24128 Bergamo, Italy
5
Department of Prosthodontics and Periodontology, Piracicaba Dental School, State University of Campinas, Piracicaba 13414-903, Brazil
6
Department of Restorative and Prosthetic Dentistry, College of Dentistry, Ohio State University, Columbus, OH 43210, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Marco Cicciù
Materials 2021, 14(7), 1814; https://doi.org/10.3390/ma14071814
Received: 24 February 2021 / Revised: 23 March 2021 / Accepted: 29 March 2021 / Published: 6 April 2021
(This article belongs to the Special Issue Advanced Biomaterials in Dentistry and Healthcare)
Silane-coating strategy has been used to bind biological compounds to the titanium surface, thereby making implant devices biologically active. However, it has not been determined if the presence of the silane coating itself is biocompatible to osseointegration. The aim of the present study was to evaluate if silane-coating affects bone formation on titanium using a rabbit model. For this, titanium screw implants (3.75 by 6 mm) were hydroxylated in a solution of H2SO4/30% H2O2 for 4 h before silane-coating with 3-aminopropyltriethoxysilane (APTES). A parallel set of titanium screws underwent only the hydroxylation process to present similar acid-etched topography as a control. The presence of the silane on the surface was checked by x-ray photoelectron spectroscopy (XPS), with scanning electron microscopy (SEM) and atomic force microscopy (AFM). A total of 40 titanium screws were implanted in the tibia of ten New Zealand rabbits in order to evaluate bone-to-implant contact (BIC) after 3 weeks and 6 weeks of healing. Silane-coated surface presented higher nitrogen content in the XPS analysis, while micro- and nano-topography of the surface remained unaffected. No difference between the groups was observed after 3 and 6 weeks of healing (p > 0.05, independent t-test), although an increase in BIC occurred over time. These results indicate that silanization of a titanium surface with APTES did not impair the bone formation, indicating that this can be a reliable tool to anchor osteogenic molecules on the surface of implant devices. View Full-Text
Keywords: titanium; osteogenesis; dental implants; implant surface; animal study titanium; osteogenesis; dental implants; implant surface; animal study
Show Figures

Figure 1

MDPI and ACS Style

Senna, P.M.; de Almeida Barros Mourão, C.F.; Mello-Machado, R.C.; Javid, K.; Montemezzi, P.; Del Bel Cury, A.A.; Meirelles, L. Silane-Coating Strategy for Titanium Functionalization Does Not Impair Osteogenesis In Vivo. Materials 2021, 14, 1814. https://doi.org/10.3390/ma14071814

AMA Style

Senna PM, de Almeida Barros Mourão CF, Mello-Machado RC, Javid K, Montemezzi P, Del Bel Cury AA, Meirelles L. Silane-Coating Strategy for Titanium Functionalization Does Not Impair Osteogenesis In Vivo. Materials. 2021; 14(7):1814. https://doi.org/10.3390/ma14071814

Chicago/Turabian Style

Senna, Plinio M.; de Almeida Barros Mourão, Carlos F.; Mello-Machado, Rafael C.; Javid, Kayvon; Montemezzi, Pietro; Del Bel Cury, Altair A.; Meirelles, Luiz. 2021. "Silane-Coating Strategy for Titanium Functionalization Does Not Impair Osteogenesis In Vivo" Materials 14, no. 7: 1814. https://doi.org/10.3390/ma14071814

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop