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Volume 14
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10.3390/ma14061504
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Communication

Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry

by
Hyunsik Choi
1,
Mina Kwon
2,
Hye Eun Choi
2,
Sei Kwang Hahn
1,* and
Ki Su Kim
2,3,*
1
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77-Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 790-784, Korea
2
School of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Korea
3
Center for Nanomedicine, Brigham and Women’s Hospital and Harvard Medical School, 45 Francis Street, Boston, MA 02115, USA
*
Authors to whom correspondence should be addressed.
Materials 2021, 14(6), 1504; https://doi.org/10.3390/ma14061504
Submission received: 15 February 2021 / Revised: 11 March 2021 / Accepted: 15 March 2021 / Published: 18 March 2021
(This article belongs to the Special Issue Advanced Materials and Systems for Biomedical Application)
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Abstract

Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via “click” chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs.
Keywords: hyaluronate; click chemistry; nanogel; noninvasive; drug delivery hyaluronate; click chemistry; nanogel; noninvasive; drug delivery

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MDPI and ACS Style

Choi, H.; Kwon, M.; Choi, H.E.; Hahn, S.K.; Kim, K.S. Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry. Materials 2021, 14, 1504. https://doi.org/10.3390/ma14061504

AMA Style

Choi H, Kwon M, Choi HE, Hahn SK, Kim KS. Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry. Materials. 2021; 14(6):1504. https://doi.org/10.3390/ma14061504

Chicago/Turabian Style

Choi, Hyunsik, Mina Kwon, Hye Eun Choi, Sei Kwang Hahn, and Ki Su Kim. 2021. "Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry" Materials 14, no. 6: 1504. https://doi.org/10.3390/ma14061504

APA Style

Choi, H., Kwon, M., Choi, H. E., Hahn, S. K., & Kim, K. S. (2021). Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry. Materials, 14(6), 1504. https://doi.org/10.3390/ma14061504

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