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Volume 14
Issue 5
10.3390/ma14051287
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Article

Pluronic F-127/Silk Fibroin for Enhanced Mechanical Property and Sustained Release Drug for Tissue Engineering Biomaterial

by
Jina Youn
1,
Joo Hee Choi
1,
Sumi Lee
1,
Seong Won Lee
1,
Byung Kwan Moon
2,
Jeong Eun Song
1 and
Gilson Khang
1,2,*
1
Department of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk 54896, Korea
2
Department of PolymerNano Science & Technology and Polymer Materials Fusion Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk 54896, Korea
*
Author to whom correspondence should be addressed.
Materials 2021, 14(5), 1287; https://doi.org/10.3390/ma14051287
Submission received: 9 February 2021 / Revised: 4 March 2021 / Accepted: 4 March 2021 / Published: 8 March 2021
(This article belongs to the Special Issue Biopolymer-Based Materials for Biomedical Engineering)
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Abstract

Herein, an injectable thermosensitive hydrogel was developed for a drug and cellular delivery system. The composite was prepared by facile physical mixing of pluronic F-127 (PF) and silk fibroin (SF) in an aqueous solution. The chemical structure, transparency, viscosity, injectability, degradation kinetic, cumulative release of dexamethasone (Dex), a type of corticosteroid drug, and size distribution of the fabricated hydrogels were characterized. Cytotoxicity of the hydrogels was also studied to verify the biocompatibility of the hydrogels. The addition of a proper amount of SF to PF not only improved the mechanical strength but also decreased the degradation rate which improved the fast rate release of hydrophobic drugs. The cytotoxicity of the hydrogel decreased when SF was added to PF in a proper amount. Overall, the results confirm that the composite of PF and SF can be a promising cell and drug delivery system for future application in tissue engineering and regenerative medicine.
Keywords: hydrogel; tissue engineering; pluronic F-127; silk fibroin hydrogel; tissue engineering; pluronic F-127; silk fibroin

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MDPI and ACS Style

Youn, J.; Choi, J.H.; Lee, S.; Lee, S.W.; Moon, B.K.; Song, J.E.; Khang, G. Pluronic F-127/Silk Fibroin for Enhanced Mechanical Property and Sustained Release Drug for Tissue Engineering Biomaterial. Materials 2021, 14, 1287. https://doi.org/10.3390/ma14051287

AMA Style

Youn J, Choi JH, Lee S, Lee SW, Moon BK, Song JE, Khang G. Pluronic F-127/Silk Fibroin for Enhanced Mechanical Property and Sustained Release Drug for Tissue Engineering Biomaterial. Materials. 2021; 14(5):1287. https://doi.org/10.3390/ma14051287

Chicago/Turabian Style

Youn, Jina, Joo Hee Choi, Sumi Lee, Seong Won Lee, Byung Kwan Moon, Jeong Eun Song, and Gilson Khang. 2021. "Pluronic F-127/Silk Fibroin for Enhanced Mechanical Property and Sustained Release Drug for Tissue Engineering Biomaterial" Materials 14, no. 5: 1287. https://doi.org/10.3390/ma14051287

APA Style

Youn, J., Choi, J. H., Lee, S., Lee, S. W., Moon, B. K., Song, J. E., & Khang, G. (2021). Pluronic F-127/Silk Fibroin for Enhanced Mechanical Property and Sustained Release Drug for Tissue Engineering Biomaterial. Materials, 14(5), 1287. https://doi.org/10.3390/ma14051287

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