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Article

Graphene on SiC Substrate as Biosensor: Theoretical Background, Preparation, and Characterization

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Solid State Electronic Department, Ioffe Institute, 194021 St. Petersburg, Russia
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Solid State Physics Department, Ioffe Institute, 194021 St. Petersburg, Russia
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Nitride Crystals Group, 194156 St. Petersburg, Russia
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Faculty of Lazer Photonics and Optoelectronics, ITMO University, 197101 St. Petersburg, Russia
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Chemical Faculty, Herzen University, 191186 St. Petersburg, Russia
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Molecular Biology of Viruses Department, Smorodintsev Research Institute of Influenza, 197376 St. Petersburg, Russia
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Author to whom correspondence should be addressed.
Academic Editor: Sergey Kukushkin
Materials 2021, 14(3), 590; https://doi.org/10.3390/ma14030590
Received: 28 December 2020 / Revised: 17 January 2021 / Accepted: 20 January 2021 / Published: 27 January 2021
(This article belongs to the Special Issue Silicon Carbide: From Fundamentals to Applications)
This work is devoted to the development and optimization of the parameters of graphene-based sensors. The graphene films used in the present study were grown on semi-insulating 6H-SiC substrates by thermal decomposition of SiC at the temperature of ~1700 °C. The results of measurements by Auger and Raman spectroscopies confirmed the presence of single-layer graphene on the silicon carbide surface. Model approach to the theory of adsorption on epitaxial graphene is presented. It is demonstrated that the Green-function method in conjunction with the simple substrate models permit one to obtain analytical results for the charge transfer between adsorbed molecules and substrate. The sensor structure was formed on the graphene film by laser. Initially, a simpler gas sensor was made. The sensors developed in this study demonstrated sensitivity to the NO2 concentration at the level of 1–0.01 ppb. The results obtained in the course of development and the results of testing of the graphene-based sensor for detection of protein molecules are also presented. The biosensor was fabricated by the technology previously developed for the gas sensor. The working capacity of the biosensor was tested with an immunochemical system constituted by fluorescein and monoclonal antibodies (mAbs) binding this dye. View Full-Text
Keywords: graphene; SiC; sublimation; Auger and Raman spectroscopies; Green-function method; graphene gas sensor; grapheme biosensor graphene; SiC; sublimation; Auger and Raman spectroscopies; Green-function method; graphene gas sensor; grapheme biosensor
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MDPI and ACS Style

Lebedev, A.A.; Davydov, S.Y.; Eliseyev, I.A.; Roenkov, A.D.; Avdeev, O.; Lebedev, S.P.; Makarov, Y.; Puzyk, M.; Klotchenko, S.; Usikov, A.S. Graphene on SiC Substrate as Biosensor: Theoretical Background, Preparation, and Characterization. Materials 2021, 14, 590. https://doi.org/10.3390/ma14030590

AMA Style

Lebedev AA, Davydov SY, Eliseyev IA, Roenkov AD, Avdeev O, Lebedev SP, Makarov Y, Puzyk M, Klotchenko S, Usikov AS. Graphene on SiC Substrate as Biosensor: Theoretical Background, Preparation, and Characterization. Materials. 2021; 14(3):590. https://doi.org/10.3390/ma14030590

Chicago/Turabian Style

Lebedev, Alexander A., Sergey Y. Davydov, Ilya A. Eliseyev, Alexander D. Roenkov, Oleg Avdeev, Sergey P. Lebedev, Yurii Makarov, Mikhail Puzyk, Sergey Klotchenko, and Alexander S. Usikov 2021. "Graphene on SiC Substrate as Biosensor: Theoretical Background, Preparation, and Characterization" Materials 14, no. 3: 590. https://doi.org/10.3390/ma14030590

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