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Review

Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing

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Associated Lab for Green Chemistry (LAQV), REQUIMTE, Department of Chemical Sciences—Applied Chemistry Lab, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
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Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal
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Center of Marine Sciences (CCMAR), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal
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Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal
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Department of Bioengineering, iBB—Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
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Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Katarzyna Winnicka
Materials 2021, 14(15), 4257; https://doi.org/10.3390/ma14154257
Received: 14 July 2021 / Revised: 23 July 2021 / Accepted: 25 July 2021 / Published: 30 July 2021
(This article belongs to the Special Issue Polymer-Based Nanoparticles for Drug Delivery Applications)
Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers. View Full-Text
Keywords: insulin; wound healing; nanomedicine; topical delivery; wounds; burns; polymer nanoparticle; lipid nanoparticle; inorganic nanoparticle insulin; wound healing; nanomedicine; topical delivery; wounds; burns; polymer nanoparticle; lipid nanoparticle; inorganic nanoparticle
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MDPI and ACS Style

Macedo, A.S.; Mendes, F.; Filipe, P.; Reis, S.; Fonte, P. Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing. Materials 2021, 14, 4257. https://doi.org/10.3390/ma14154257

AMA Style

Macedo AS, Mendes F, Filipe P, Reis S, Fonte P. Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing. Materials. 2021; 14(15):4257. https://doi.org/10.3390/ma14154257

Chicago/Turabian Style

Macedo, Ana S., Francisca Mendes, Patrícia Filipe, Salette Reis, and Pedro Fonte. 2021. "Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing" Materials 14, no. 15: 4257. https://doi.org/10.3390/ma14154257

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