Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Zein-NIC NPs
2.3. Preparation of BSA-Coated Zein-NIC NPs
2.4. Drug Content Analysis and InVitro Drug Release Studies
2.5. Colloidal Stability
2.6. Characterizations
2.7. Statistical Analysis
3. Results and Discussion
3.1. Synthesis and Characterization of Injectable Formulation
3.1.1. XRD, FT-IR, and NMR Analysis
3.2. Particle Size, Zeta, and Surface Morphology Analyses
3.3. In Vitro Drug Release Studies
4. Clinical Perspectives
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Samples | PDI (a.u.) |
---|---|
NIC NPs | 0.385 ± 0.026 |
Zein-NIC NPs | 0.314 ± 0.013 |
BSA-Zein-NIC NPs | 0.032 ± 0.005 ** |
Samples | Drug Content (%) |
---|---|
Zein-NIC NPs | 10.08 ± 0.95 |
BSA-Zein-NIC NPs | 3.31 ± 0.041 |
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Rejinold N, S.; Choi, G.; Piao, H.; Choy, J.-H. Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19. Materials 2021, 14, 3792. https://doi.org/10.3390/ma14143792
Rejinold N S, Choi G, Piao H, Choy J-H. Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19. Materials. 2021; 14(14):3792. https://doi.org/10.3390/ma14143792
Chicago/Turabian StyleRejinold N, Sanoj, Goeun Choi, Huiyan Piao, and Jin-Ho Choy. 2021. "Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19" Materials 14, no. 14: 3792. https://doi.org/10.3390/ma14143792