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Open AccessArticle

Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties

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Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410081 Oradea, Romania
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Biomedical Sciences Doctoral School, Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410081 Oradea, Romania
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Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”, Via Appia Nuova 1411, 00178 Rome, Italy
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Advanced Materials Research Laboratory, University of Oradea, 1 Universitatii Street, 410087 Oradea, Romania
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Department Materials Science and Engineering, University Politehnica of Bucharest, Splaiul Independentei 313, sector 6, 060032 Bucharest, Romania
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Department of Industrial Engineering, University “Tor Vergata” Rome, via del Politecnico 1, 00133 Rome, Italy
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INFN National Laboratory of Frascati, via Enrico Fermi 40, 00044 Frascati, Italy
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Department of Chemistry, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
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Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Materials 2020, 13(9), 2077; https://doi.org/10.3390/ma13092077
Received: 19 March 2020 / Revised: 20 April 2020 / Accepted: 21 April 2020 / Published: 1 May 2020
The properties of poly(vinyl alcohol) (PVA)-based composites recommend this material as a good candidate for the replacement of damaged cartilage, subchondral bone, meniscus, humeral joint and other orthopedic applications. The manufacturing process can be manipulated to generate the desired biomechanical properties. However, the main shortcomings of PVA hydrogels are related to poor strength and bioactivity. To overcome this situation, reinforcing elements are added to the PVA matrix. The aim of our work was to develop and characterize a novel composition based on PVA reinforced with Se-doped TiO2 nanoparticles and natural hydroxyapatite (HA), for possible orthopedic applications. The PVA/Se-doped TiO2 composites with and without HA were structurally investigated by FTIR and XRD, in order to confirm the incorporation of the inorganic phase in the polymeric structure, and by SEM and XRF, to evidence the ultrastructural details and dispersion of nanoparticles in the PVA matrix. Both the mechanical and structural properties of the composites demonstrated a synergic reinforcing effect of HA and Se-doped TiO2 nanoparticles. Moreover, the tailorable properties of the composites were proved by the viability and differentiation potential of the bone marrow mesenchymal stem cells (BMMSC) to osteogenic, chondrogenic and adipogenic lineages. The novel hybrid PVA composites show suitable structural, mechanical and biological features to be considered as a promising biomaterial for articular cartilage and subchondral bone repair. View Full-Text
Keywords: PVA (poly(vinyl alcohol)); composites; hydroxyapatite; selenium; titania; nanoparticles; BMMSC differentiation PVA (poly(vinyl alcohol)); composites; hydroxyapatite; selenium; titania; nanoparticles; BMMSC differentiation
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MDPI and ACS Style

Cavalu, S.; Fritea, L.; Brocks, M.; Barbaro, K.; Murvai, G.; Costea, T.O.; Antoniac, I.; Verona, C.; Romani, M.; Latini, A.; Zilli, R.; Rau, J.V. Novel Hybrid Composites Based on PVA/SeTiO2 Nanoparticles and Natural Hydroxyapatite for Orthopedic Applications: Correlations between Structural, Morphological and Biocompatibility Properties. Materials 2020, 13, 2077.

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