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Review

Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment

1
Department of Medical Biotechnology, Poznan University of Medical Sciences, 61-866 Poznan, Poland
2
Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, 61-866 Poznan, Poland
*
Author to whom correspondence should be addressed.
Materials 2020, 13(21), 4946; https://doi.org/10.3390/ma13214946
Received: 12 October 2020 / Revised: 30 October 2020 / Accepted: 31 October 2020 / Published: 4 November 2020
(This article belongs to the Special Issue Silk-Based Biomaterials)
Although progress is observed in cancer treatment, this disease continues to be the second leading cause of death worldwide. The current understanding of cancer indicates that treating cancer should not be limited to killing cancer cells alone, but that the target is the complex tumor microenvironment (TME). The application of nanoparticle-based drug delivery systems (DDS) can not only target cancer cells and TME, but also simultaneously resolve the severe side effects of various cancer treatment approaches, leading to more effective, precise, and less invasive therapy. Nanoparticles based on proteins derived from silkworms’ cocoons (like silk fibroin and sericins) and silk proteins from spiders (spidroins) are intensively explored not only in the oncology field. This natural-derived material offer biocompatibility, biodegradability, and simplicity of preparation methods. The protein-based material can be tailored for size, stability, drug loading/release kinetics, and functionalized with targeting ligands. This review summarizes the current status of drug delivery systems’ development based on proteins derived from silk fibroin, sericins, and spidroins, which application is focused on systemic cancer treatment. The nanoparticles that deliver chemotherapeutics, nucleic acid-based therapeutics, natural-derived agents, therapeutic proteins or peptides, inorganic compounds, as well as photosensitive molecules, are introduced. View Full-Text
Keywords: silk; particles; cancer; silk fibroin; spidroin; sericin; bioengineering; drug delivery silk; particles; cancer; silk fibroin; spidroin; sericin; bioengineering; drug delivery
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MDPI and ACS Style

Florczak, A.; Grzechowiak, I.; Deptuch, T.; Kucharczyk, K.; Kaminska, A.; Dams-Kozlowska, H. Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment. Materials 2020, 13, 4946. https://doi.org/10.3390/ma13214946

AMA Style

Florczak A, Grzechowiak I, Deptuch T, Kucharczyk K, Kaminska A, Dams-Kozlowska H. Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment. Materials. 2020; 13(21):4946. https://doi.org/10.3390/ma13214946

Chicago/Turabian Style

Florczak, Anna, Inga Grzechowiak, Tomasz Deptuch, Kamil Kucharczyk, Alicja Kaminska, and Hanna Dams-Kozlowska. 2020. "Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment" Materials 13, no. 21: 4946. https://doi.org/10.3390/ma13214946

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