Next Article in Journal
POM/EVA Blends with Future Utility in Fused Deposition Modeling
Previous Article in Journal
Using AE Signals to Investigate the Fracture Process in an Al–Ti Laminate
Previous Article in Special Issue
Modified Starch as a Filter Controller in Water-Based Drilling Fluids
Open AccessArticle

Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds

1
Departamento de Ingeniería Química, Biotecnología y Materiales, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Beauchef 851, Santiago 8370456, Chile
2
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany
3
Laboratory of Nanobiomaterials, Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Olivos 943 Independencia, Santiago 8380544, Chile
4
Millennium Nuclei in Soft Smart Mechanical Metamaterials, Universidad de Chile, Santiago 8370456, Chile
*
Authors to whom correspondence should be addressed.
Materials 2020, 13(13), 2908; https://doi.org/10.3390/ma13132908
Received: 12 May 2020 / Revised: 10 June 2020 / Accepted: 15 June 2020 / Published: 29 June 2020
(This article belongs to the Special Issue Polymeric Materials: Surfaces, Interfaces and Bioapplications II)
Biodegradable polymer scaffolds filled with bioactive glass particles doped with therapeutic metal ions are a novel and promising strategy to repair critical-sized bone defects. In this study, scaffolds based on a poly (D, L-lactide acid) (PDLLA) matrix filled with un-doped and Cu-, Zn- and CuZn-doped bioactive glass particles were produced by freeze-drying and a salt-leaching method. The effects of the doping and content of the glass particles (10 and 30 wt.%) on the morphology, compression properties, apatite formation, and degradation behavior of the scaffolds were evaluated. The scaffolds presented high porosity (~93%) with pores ranged from 100 to 400 μm interconnected by smaller pores and this porosity was kept after the glass particles incorporation. The glass particles reinforced the polymer scaffolds with improvements as high as 130% in elastic moduli, and further promoted the apatite formation on the scaffold surface, both properties depending on the amount and type of filler. The bioactive glass particles boosted the scaffold degradation with the PDLLA/un-doped glass scaffold showing the highest rate, but still retaining structural and dimensional integrity. Our findings show that the incorporation of un-doped and metal-doped bioactive glasses increases the mechanical strength, promotes the bioactivity and modifies the degradation profile of the resulting polymer/glass scaffolds, making them better candidates for bone repair. View Full-Text
Keywords: polymer scaffolds; bioactive glass particles; copper- and zinc-doped glasses; mechanical properties; degradation; in vitro bioactivity; bone repair polymer scaffolds; bioactive glass particles; copper- and zinc-doped glasses; mechanical properties; degradation; in vitro bioactivity; bone repair
Show Figures

Figure 1

MDPI and ACS Style

Bejarano, J.; Boccaccini, A.R.; Covarrubias, C.; Palza, H. Effect of Cu- and Zn-Doped Bioactive Glasses on the In Vitro Bioactivity, Mechanical and Degradation Behavior of Biodegradable PDLLA Scaffolds. Materials 2020, 13, 2908.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop