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Materials 2019, 12(5), 828; https://doi.org/10.3390/ma12050828

Monodisperse Fe3O4/SiO2 and Fe3O4/SiO2/PPy Core-Shell Composite Nanospheres for IBU Loading and Release

1
School of Chemistry and Environmental Engineering, Institute of Applied Chemistry, Shanxi Datong University, Datong 037009, China
2
Department of Chemistry, Xinzhou Teachers University, Xinzhou 034000, China
*
Authors to whom correspondence should be addressed.
Received: 7 February 2019 / Revised: 28 February 2019 / Accepted: 3 March 2019 / Published: 11 March 2019
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Abstract

The magnetic targeting drug delivery system is an effective way of targeting therapy. In this study, the monodisperse Fe3O4 nanoparticles with a particles size of about 180 nm were first prepared via a solvothermal method. Subsequently, the core-shell structure Fe3O4/SiO2 and Fe3O4/SiO2/polypyrrole (PPy) composite nanospheres were successfully synthesized by coating Fe3O4 nanoparticles with SiO2 shell layer using the Stöber method and PPy shell by solvothermal method in turn. The as-prepared nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Ultraviolet-Visible spectrophotometer (UV-Vis). The results indicated that the as-prepared composite nanospheres displayed a well-defined core-shell structure and monodispersity. The thicknesses of SiO2 shell and PPy shell were ~6 nm and ~19 nm, respectively. Additionally, the as-prepared nanoparticles exhibited high saturation magnetization of 104 emu/g, 77 emu/g, and 24 emu/g, and have great potential applications in drug delivery. The drug loading and drug release of the Fe3O4/SiO2 and Fe3O4/SiO2/PPy composite nanospheres to ibuprofen (IBU) under stirring and ultrasonication were investigated. Their drug loading efficiency and drug release efficiency under ultrasonication were all higher than 33% and 90%, respectively. The drug release analyses showed sustained release of IBU from nanospheres and followed the Korsmeyer-Peppas model. View Full-Text
Keywords: Fe3O4/SiO2; Fe3O4/SiO2/PPy; core-shell structure; magnetic property; drug loading; drug release; Korsmeyer-Peppas model Fe3O4/SiO2; Fe3O4/SiO2/PPy; core-shell structure; magnetic property; drug loading; drug release; Korsmeyer-Peppas model
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Shen, L.; Li, B.; Qiao, Y.; Song, J. Monodisperse Fe3O4/SiO2 and Fe3O4/SiO2/PPy Core-Shell Composite Nanospheres for IBU Loading and Release. Materials 2019, 12, 828.

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