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Open AccessFeature PaperArticle

The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver

1
Department of Materials Science and Engineering, Monash University, Melbourne 3800, Australia
2
Department of Mechanical Engineering, The University of Western Australia, Nedlands 6907, Australia
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A. A. Baikov Institute of Metallurgy and Materials Science of the RAS, Moscow 119334, Russia
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National University of Science and Technology “MISIS”, Moscow 119049, Russia
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N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Moscow 115478, Russia
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Institute of Physics of Advanced Materials, Ufa State Aviation Technical University, Ufa 450000, Russia
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Institute of Solid State Physics and Chernogolovka Scientific Center of the Russian Academy of Sciences, Chernogolovka 142432, Russia
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Institute of Materials Research, Division Metallic Biomaterials, Helmholtz-Zentrum Geesthacht (HZG), 21502 Geesthacht, Germany
*
Author to whom correspondence should be addressed.
Materials 2019, 12(23), 3832; https://doi.org/10.3390/ma12233832
Received: 27 September 2019 / Revised: 12 November 2019 / Accepted: 18 November 2019 / Published: 21 November 2019
(This article belongs to the Special Issue Alloys for Biomedical Application)
The effect of equal-channel angular pressing (ECAP) on the microstructure, texture, mechanical properties, corrosion resistance and cytotoxicity of two magnesium-silver alloys, Mg-2.0%Ag and Mg-4.0%Ag, was studied. Their average grain size was found to be reduced to 3.2 ± 1.4 μm and 2.8 ± 1.3 μm, respectively. Despite the substantial grain refinement, a drop in the strength characteristics of the alloys was observed, which can be attributed to the formation of inclined basal texture. On a positive side, an increase in tensile ductility to ~34% for Mg-2.0%Ag and ~27% for Mg-4.0%Ag was observed. This effect can be associated with the activity of basal and prismatic slip induced by ECAP. One of the ECAP regimes tested gave rise to a drop in the corrosion resistance of both alloys. An interesting observation was a cytotoxic effect both alloys had on tumor cells in vitro. This effect was accompanied with the release of lactate dehydrogenase, an increase in oxidative stress, coupled with the induction of NO-ions and an increase in the content of such markers of apoptosis as Annexin V and Caspase 3/7. Differences in the chemical composition and the processing history-dependent microstructure of the alloys did not have any significant effect on the magnitude of their antiproliferative effect. View Full-Text
Keywords: biomedical materials; magnesium alloys; equal-channel angular pressing; microstructure; texture; mechanical properties; cytotoxicity in vitro biomedical materials; magnesium alloys; equal-channel angular pressing; microstructure; texture; mechanical properties; cytotoxicity in vitro
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MDPI and ACS Style

Estrin, Y.; Martynenko, N.; Anisimova, N.; Temralieva, D.; Kiselevskiy, M.; Serebryany, V.; Raab, G.; Straumal, B.; Wiese, B.; Willumeit-Römer, R.; Dobatkin, S. The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver. Materials 2019, 12, 3832.

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