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Open AccessArticle

Myofibroblast Gene Expression Profile after Tooth Extraction in the Rabbit

Tuscan Dental Institute, Versilia General Hospital, 55041 Lido di Camaiore, Italy
Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56124 Pisa, Italy
Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv 61503, Israel
Section of Surgical Pathology, University Hospital of Pisa, 56124 Pisa, Italy
Author to whom correspondence should be addressed.
Materials 2019, 12(22), 3697;
Received: 23 September 2019 / Revised: 29 October 2019 / Accepted: 7 November 2019 / Published: 9 November 2019
(This article belongs to the Section Biomaterials)
After tooth extraction, the alveolar bone tends to shrink in volume, especially on the vestibular side. The role of myofibroblasts in bone remodeling has not been sufficiently investigated. The aim of the present study was to explore the gene expression related to myofibroblasts presence and activity during a 90-day healing period after tooth extraction. The study included 36 rabbits, and a single tooth extraction was performed on each rabbit. The extractive sockets were randomly distributed to natural healing or to scarification of the wound. The sacrifices were staggered in such a manner that animals contributed with sockets representing 2, 7, 15, 30, 60, and 90 days of healing. Nanostring technology was used to evaluate the expression of a wide panel consisting in 148 genes related to the activation, induction, and suppression of myofibroblasts, socket microenvironment, and autophagy. We found that the expression profile of this custom panel was time-related. The post-extractive socket was subjected to significant gene expression changes after 15 days: the genes involved in the induction of myofibroblasts were up-regulated in the first 15-day period and down-regulated during the rest of the follow-up. The study suggested that myofibroblasts play a major role in the immediate 15-day period following tooth extraction. View Full-Text
Keywords: wound healing; gene expression; fibroblasts; alveolar bone wound healing; gene expression; fibroblasts; alveolar bone
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Marconcini, S.; Denaro, M.; Cosola, S.; Gabriele, M.; Toti, P.; Mijiritsky, E.; Proietti, A.; Basolo, F.; Giammarinaro, E.; Covani, U. Myofibroblast Gene Expression Profile after Tooth Extraction in the Rabbit. Materials 2019, 12, 3697.

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