Purpose: To analyze in vitro the mechanical behavior of five types of complete coverage crowns fabricated from different materials. Materials and methods: Seventy-five full coverage crowns were divided into five groups according to material: Group I, metal core with feldspathic ceramic covering (MC- control group); Group II, zirconia core with feldspathic ceramic covering (CZ); Group III, tetragonal monolithic zirconia (TMZ); Group IV, cubic monolithic zirconia (CMZ); Group V, high molecular weight polymethyl methacrylate (PMMAG) doped with graphene nanoparticles. All crowns underwent in vitro fatiguing by dynamic loading in wet conditions to simulate the masticatory forces to which prosthodontic materials are subject in the oral medium. Lastly, fracture resistance was evaluated by static compression testing. Results: The fracture resistance values obtained were as follows: Group MC, 2443.6 ± 238.6 N; Group CZ, 2095.4 ± 329.2 N; Group TMZ, 2494.6 ± 236.6 N; Group CMZ, 1523.6 ± 325.2 N; and Group PMMAG, 1708.9 ± 386.6 N. Group MC presented higher strength with statistically significant differences in comparison with Groups CZ (P
= 0.002), CMZ (P
< 0.001), and PMMAG (P
< 0.001). Weibull distribution showed less probability of cumulative biomechanical failure in Groups MC and TMZ. Conclusions: Metal-ceramic and tetragonal zirconia showed high fracture resistance, while cubic zirconia and PMMA doped with graphene nanoparticles obtained lower values.
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