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Open AccessArticle

Human Mesenchymal Stem Cell Combined with a New Strontium-Enriched Bioactive Glass: An ex-vivo Model for Bone Regeneration

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Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Via P. Vivarelli 10, 41125 Modena, Italy
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Department of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Hospital of Modena, Via del Pozzo 71, 44125 Modena, Italy
3
Scientific and Technological Park of Medicine “Mario Veronesi”, via 29 Maggio 6, 41037 Mirandola, Italy
*
Author to whom correspondence should be addressed.
Materials 2019, 12(21), 3633; https://doi.org/10.3390/ma12213633
Received: 2 October 2019 / Revised: 30 October 2019 / Accepted: 31 October 2019 / Published: 5 November 2019
(This article belongs to the Special Issue Spotlight on Bioactive Glasses and Their Related Composites)
A 3D cellular model that mimics the potential clinical application of a biomaterial is here applied for the first time to a bioactive glass, in order to assess its biological potential. A recently developed bioactive glass (BGMS10), whose composition contained strontium and magnesium, was produced in the form of granules and fully investigated in terms of biocompatibility in vitro. Apart from standard biological characterization (Simulated Body Fluid (SBF) testing and biocompatibility as per ISO10993), human bone marrow mesenchymal stromal/stem cells (BM-MSCs) were used to investigate the performance of the bioactive glass granules in an innovative 3D cellular model. The results showed that BGMS10 supported human BM-MSCs adhesion, colonization, and bone differentiation. Thus, bioactive glass granules seem to drive osteogenic differentiation and thus look particularly promising for orthopedic applications, bone tissue engineering and regenerative medicine. View Full-Text
Keywords: bioactive glass; mesenchymal stem cells; bone regeneration; cell culture; strontium; magnesium bioactive glass; mesenchymal stem cells; bone regeneration; cell culture; strontium; magnesium
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MDPI and ACS Style

Bellucci, D.; Veronesi, E.; Strusi, V.; Petrachi, T.; Murgia, A.; Mastrolia, I.; Dominici, M.; Cannillo, V. Human Mesenchymal Stem Cell Combined with a New Strontium-Enriched Bioactive Glass: An ex-vivo Model for Bone Regeneration. Materials 2019, 12, 3633.

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