Next Article in Journal
Preparation and Characterization of Nanoporous Activated Carbon Derived from Prawn Shell and Its Application for Removal of Heavy Metal Ions
Previous Article in Journal
Effect of Scanning and Support Strategies on Relative Density of SLM-ed H13 Steel in Relation to Specimen Size
Previous Article in Special Issue
Development of Organosilicon-Based Superhydrophobic Coatings through Atmospheric Pressure Plasma Polymerization of HMDSO in Nitrogen Plasma
Article Menu

Export Article

Open AccessReview
Materials 2019, 12(2), 240;

Biocompatibility of Plasma-Treated Polymeric Implants

Department of Surface Engineering and Optoelectronics, Jožef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia
Received: 30 November 2018 / Revised: 25 December 2018 / Accepted: 2 January 2019 / Published: 12 January 2019
(This article belongs to the Special Issue Surface Modification to Improve Properties of Materials)
Full-Text   |   PDF [1497 KB, uploaded 12 January 2019]   |  
  |   Review Reports


Cardiovascular diseases are one of the main causes of mortality in the modern world. Scientist all around the world are trying to improve medical treatment, but the success of the treatment significantly depends on the stage of disease progression. In the last phase of disease, the treatment is possible only by implantation of artificial graft. Most commonly used materials for artificial grafts are polymer materials. Despite different industrial procedures for graft fabrication, their properties are still not optimal. Grafts with small diameters (<6 mm) are the most problematic, because the platelets are more likely to re-adhere. This causes thrombus formation. Recent findings indicate that platelet adhesion is primarily influenced by blood plasma proteins that adsorb to the surface immediately after contact of a synthetic material with blood. Fibrinogen is a key blood protein responsible for the mechanisms of activation, adhesion and aggregation of platelets. Plasma treatment is considered as one of the promising methods for improving hemocompatibility of synthetic materials. Another method is endothelialization of materials with Human Umbilical Vein Endothelial cells, thus forming a uniform layer of endothelial cells on the surface. Extensive literature review led to the conclusion that in this area, despite numerous studies there are no available standardized methods for testing the hemocompatibility of biomaterials. In this review paper, the most promising methods to gain biocompatibility of synthetic materials are reported; several hypotheses to explain the improvement in hemocompatibility of plasma treated polymer surfaces are proposed. View Full-Text
Keywords: biomaterial; polymer; plasma; functionalization; surface properties; thrombosis; hemocompatibility; endothealization; vascular graft; biocompatibility; endothelial cells biomaterial; polymer; plasma; functionalization; surface properties; thrombosis; hemocompatibility; endothealization; vascular graft; biocompatibility; endothelial cells

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Recek, N. Biocompatibility of Plasma-Treated Polymeric Implants. Materials 2019, 12, 240.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top