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Biomimetic Polymer-Based Engineered Scaffolds for Improved Stem Cell Function

1
The Institute of Forest Science, Kangwon National University, Chuncheon-24341, Korea
2
Department of Biosystems Engineering, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon-24341, Korea
*
Author to whom correspondence should be addressed.
Materials 2019, 12(18), 2950; https://doi.org/10.3390/ma12182950
Received: 14 August 2019 / Revised: 6 September 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
Scaffolds are considered promising materials for tissue engineering applications due to their unique physiochemical properties. The high porosity and adequate mechanical properties of the scaffolds facilitate greater cell adhesion, proliferation, and differentiation. Stem cells are frequently applied in tissue engineering applications due to their excellent potential. It has been noted that cell functions are profoundly affected by the nature of the extracellular matrix (ECM). Naturally derived ECM contains the bioactive motif that also influences the immune response of the organism. The properties of polymer scaffolds mean they can resemble the native ECM and can regulate cellular responses. Various techniques such as electrospinning and 3D printing, among others, are frequently used to fabricate polymer scaffolds, and their cellular responses are different with each technique. Furthermore, enhanced cell viability, as well as the differentiation ability of stem cells on the surface of scaffolds, opens a fascinating approach to the formation of ECM-like environments for tissue engineering applications. View Full-Text
Keywords: scaffolds; extracellular matrices; cell functions; stem cells; tissue engineering scaffolds; extracellular matrices; cell functions; stem cells; tissue engineering
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Patel, D.K.; Lim, K.-T. Biomimetic Polymer-Based Engineered Scaffolds for Improved Stem Cell Function. Materials 2019, 12, 2950.

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