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Open AccessArticle

Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells

1
Leibniz Institute of Solid State and Material Research Dresden, 01069 Dresden, Germany
2
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy
3
Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, NSW 2031, Australia
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ARC Centre of Excellence for Convergent BioNano Science and Technology, Australian Centre for NanoMedicine, UNSW Sydney, NSW 2052, Australia
5
School of Women’s and Children’s Health, Faculty of Medicine, UNSW Sydney, NSW 2052, Australia
*
Author to whom correspondence should be addressed.
Materials 2019, 12(18), 2889; https://doi.org/10.3390/ma12182889
Received: 28 June 2019 / Revised: 2 September 2019 / Accepted: 4 September 2019 / Published: 6 September 2019
(This article belongs to the Special Issue Carbon Nanotubes 2018)
A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1s signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299. View Full-Text
Keywords: multi-walled carbon nanotubes; nanohybrids; methotrexate; pH responsivity; lung cancer multi-walled carbon nanotubes; nanohybrids; methotrexate; pH responsivity; lung cancer
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Cirillo, G.; Vittorio, O.; Kunhardt, D.; Valli, E.; Voli, F.; Farfalla, A.; Curcio, M.; Spizzirri, U.G.; Hampel, S. Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells. Materials 2019, 12, 2889.

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