Preparation, Characterization and Application of Multi-Mode Imaging Functional Graphene Au-Fe3O4 Magnetic Nanocomposites
Abstract
:1. Introduction
2. Experimental Reagents and Instruments
2.1. Experimental Reagents
2.2. Experimental Instruments
3. Experimentation
3.1. Preparation of Au-Fe3O4 Nanoparticles
3.2. Preparation of 1a
3.3. Preparation of 1b
3.4. Preparation of 1c
3.5. Preparation of 1d
3.6. Drug Release Test
4. Results and Discussion
4.1. Morphological Changes of Au-Fe3O4 Nanoparticles on GO Surface before and after Modification
4.2. Thermo Gravimetric Analysis of GO and GO-PEI
4.3. Infrared Analysis of Graphene-Based Au-Fe3O4 Magnetic Nanocomposites
4.4. Magnetic Change of Au-Fe3O4 before and after Modification
4.5. Graphene-Based Au-Fe3O4 Magnetic Nanocomposites and UV Analysis during Drug Loading
4.6. Loading Capacity of Graphene-Based Au-Fe3O4 Magnetic Nanocomposites for DOX
4.7. Release of DOX Loaded Graphene-Based Au-Fe3O4 Magnetic Nanocomposites under Different pH Conditions
4.8. Loading Capacity of Graphene-Based Au-Fe3O4 Magnetic Nanocomposites for SN38
4.9. Release of SN38 Loaded Graphene-Based Au-Fe3O4 Magnetic Nanocomposites under Different pH Conditions
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Reagents | Specifications | Manufacturer |
---|---|---|
Ferric acetylacetonate | A.R. | Shanghai Aladdin Biochemical Technology Co., Ltd, Shanghai, China |
N-(4-Pyridyl)dimethylamine | A.R. | Shanghai Aladdin Biochemical Technology Co., Ltd, Shanghai, China |
3,4- protocatechualdehyde oleamine | A.R. | Sigma–Aldrich, St. Louis, MO, USA |
NHydroxybenzotrizole | A.R. | Sigma–Aldrich, St. Louis, MO, USA |
Dopamine | A.R. | Sigma–Aldrich, St. Louis, MO, USA |
Thioglycolic acid; mercaptoacetic acid | A.R. | Sigma–Aldrich, St. Louis, MO, USA |
Anthranilic acid | A.R. | Sigma–Aldrich, St. Louis, MO, USA |
Folic acid | A.R. | Sigma–Aldrich, St. Louis, MO, USA |
Isatoic anhydride | A.R. | Sigma–Aldrich, St. Louis, MO, USA |
Instrument | Model | Manufacturer |
---|---|---|
Fluorescence spectrophotometer | F4500 | Hitachi, Ltd, Tokyo, Japan |
Transmission electron microscope | HT7800 | Hitachi, Ltd, Tokyo, Japan |
X-ray Photoelectron Spectrometer | ESCALAB 250 XI | Thermo Fisher Scientific, Hillsboro, OR, USA |
Fourier transformation infrared spectrometer | IR-960 | Tianjin Ruian Technology Co., Ltd, Tianjin, China |
Ultraviolet visible spectrophotometer | UV 1750 | Shimazduo, Kyoto, Japan |
X-ray diffractometer | D8 Advance | BRUKER AXS GMBH, Karlsruhe, Germany |
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Sun, W.; Huang, S.; Zhang, S.; Luo, Q. Preparation, Characterization and Application of Multi-Mode Imaging Functional Graphene Au-Fe3O4 Magnetic Nanocomposites. Materials 2019, 12, 1978. https://doi.org/10.3390/ma12121978
Sun W, Huang S, Zhang S, Luo Q. Preparation, Characterization and Application of Multi-Mode Imaging Functional Graphene Au-Fe3O4 Magnetic Nanocomposites. Materials. 2019; 12(12):1978. https://doi.org/10.3390/ma12121978
Chicago/Turabian StyleSun, Wei, Shaowen Huang, Siyu Zhang, and Qi Luo. 2019. "Preparation, Characterization and Application of Multi-Mode Imaging Functional Graphene Au-Fe3O4 Magnetic Nanocomposites" Materials 12, no. 12: 1978. https://doi.org/10.3390/ma12121978