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Open AccessArticle

Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering

1
Institute of Macromolecular Compounds, Russian Academy of Sciences, V.O. Bolshoi pr. 31, 199004 St. Petersburg, Russia
2
Saint-Petersburg State University of Industrial Technologies and Design, ul. Bolšaja Morskaja 18, 191183 St. Petersburg, Russia
3
Anton Paar GmbH, Anton-Paar-Str. 20, 8054 Graz, Austria
4
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio 7, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Materials 2019, 12(11), 1874; https://doi.org/10.3390/ma12111874
Received: 11 April 2019 / Revised: 30 May 2019 / Accepted: 6 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Chitosan-based Materials)
This paper discusses the mechanical and physicochemical properties of film matrices based on chitosan, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It is shown that with the introduction of chitin nanofibrils as a filler, the mechanical stability of the composite materials increases. By varying the concentration of chitin nanofibrils, it is possible to obtain a spectrum of samples with different bioactive properties for the growth of human dermal fibroblasts. Film matrices based on the nanocomposite of chitosan and 5 wt % chitin nanofibrils have an optimal balance of mechanical and physicochemical properties and bioactivity in relation to the culture of human dermal fibroblasts. View Full-Text
Keywords: chitosan; chitin nanofibrils; composite matrix; tissue engineering chitosan; chitin nanofibrils; composite matrix; tissue engineering
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Smirnova, N.V.; Kolbe, K.A.; Dresvyanina, E.N.; Grebennikov, S.F.; Dobrovolskaya, I.P.; Yudin, V.E.; Luxbacher, T.; Morganti, P. Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering. Materials 2019, 12, 1874.

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