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Materials 2019, 12(6), 847;

Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology

University of Maribor, Faculty of Mechanical Engineering, Institute for Engineering Materials and Design, Smetanova 17, 2000 Maribor, Slovenia
Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia
University Medical Centre Maribor, Department of Otorhinolaryngology, Cervical and Maxillofacial Surgery, Ljubljanska ulica 5, 2000 Maribor, Slovenia
Authors to whom correspondence should be addressed.
Received: 8 February 2019 / Revised: 7 March 2019 / Accepted: 8 March 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Chitosan-based Materials)
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Silicones are widely used medical materials that are also applied for tympanostomy tubes with a trending goal to functionalise the surface of the latter to enhance the healing of ear inflammations and other ear diseases, where such medical care is required. This study focuses on silicone surface treatment with various antimicrobial coatings. Polysaccharide coatings in the form of chitosan nanoparticles alone, or with an embedded drug mixture composed of amoxicillin/clavulanic acid (co-amoxiclav) were prepared and applied onto silicone material. Plasma activation was also used as a pre-treatment for activation of the material’s surface for better adhesion of the coatings. The size of the nanoparticles was measured using the DLS method (Dynamic Light Scattering), stability of the dispersion was determined with zeta potential measurements, whilst the physicochemical properties of functionalised silicone materials were examined using the UV-Vis method (Ultraviolet-Visible Spectroscopy), SEM (Scanning Electron Microscopy), XPS (X-Ray Photoelectron Spectroscopy). Moreover, in vitro drug release testing was used to follow the desorption kinetics and antimicrobial properties were tested by a bacterial cell count reduction assay using the standard gram-positive bacteria Staphylococcus aureus. The results show silicone materials as suitable materials for tympanostomy tubes, with the coating developed in this study showing excellent antimicrobial and biofilm inhibition properties. This implies a potential for better healing of ear inflammation, making the newly developed approach for the preparation of functionalised tympanostomy tubes promising for further testing towards clinical applications. View Full-Text
Keywords: silicone; tympanostomy tube; chitosan; nanoparticles; drug delivery; antimicrobial activity silicone; tympanostomy tube; chitosan; nanoparticles; drug delivery; antimicrobial activity

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Ajdnik, U.; Zemljič, L.F.; Bračič, M.; Maver, U.; Plohl, O.; Rebol, J. Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology. Materials 2019, 12, 847.

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