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Open AccessArticle

Alendronate Release from UHMWPE-Based Biomaterials in Relation to Particle Size of the GUR Powder for Manufacturing

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G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany
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Faculty Mechanical and Medical Engineering, Furtwangen University, Robert-Gerwig-Platz 1, 78120 Furtwangen, Germany
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Freiburg Materials Research Center (FMF) and Institute for Macromolecular Chemistry of the Albert-Ludwigs University Freiburg, Stefan-Meier-Str. 21, D-79104 Freiburg, Germany
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Author to whom correspondence should be addressed.
Materials 2019, 12(11), 1832; https://doi.org/10.3390/ma12111832
Received: 21 May 2019 / Revised: 3 June 2019 / Accepted: 4 June 2019 / Published: 6 June 2019
(This article belongs to the Section Biomaterials)
Ultra-high molecular weight polyethylene (UHMWPE) is widely used in endoprosthetics and has been the subject of countless studies. This project investigates the dependence of alendronate (AL) release on the molecular weight of the UHMWPE used (GUR1020 and GUR1050). A 0.5 wt% AL was added to the UHMWPE during the production of the moldings. In addition to the 14-day release tests, biocompatibility tests such as live dead assay, cell proliferation assay (WST) and Lactate dehydrogenase test (LDH) with MG-63 cells as well as a tensile test according to DIN EN ISO 527 were carried out. The released AL concentration was determined by HPLC. A continuous release of the AL was observed over the entire period of 2 weeks. In addition, a correlation between molar mass and AL release was demonstrated. The GUR1020 showed a release four times higher than the GUR1050. Both materials have no negative influence on the proliferation of MG-63 cells. This was also confirmed in the live/dead assay by the increase in cell count. No cytotoxicity was detected in the LDH test. The addition of 0.5 wt% AL increased the elongation at break for GUR1020 by 23% and for GUR1050 by 49%. It was demonstrated that the choice of UHMWPE has an influence on the release of AL. The particle size in particular has a strong influence on the release behavior. View Full-Text
Keywords: UHMWPE; GUR1020; GUR1050; alendronate; osteoporosis; aseptic loosening; drug release; HPLC UHMWPE; GUR1020; GUR1050; alendronate; osteoporosis; aseptic loosening; drug release; HPLC
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Seidenstuecker, M.; Weber, J.; Latorre, S.H.; Straub, B.; Matthes, U.; Friedrich, C.; Mayr, H.O.; Bernstein, A. Alendronate Release from UHMWPE-Based Biomaterials in Relation to Particle Size of the GUR Powder for Manufacturing. Materials 2019, 12, 1832.

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