Next Article in Journal
Preparation and Characterization of Magnesium Alloy Containing Al2Y Particles
Next Article in Special Issue
Interference of Biodegradable Plastics in the Polypropylene Recycling Process
Previous Article in Journal
Layer by Layer Mesoporous Silica-Hyaluronic Acid-Cyclodextrin Bifunctional “Lamination”: Study of the Application of Fluorescent Probe and Host–Guest Interactions in the Drug Delivery Field
Previous Article in Special Issue
Ring Wrinkle Patterns with Continuously Changing Wavelength Produced Using a Controlled-Gradient Light Field
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview

Developing a New Generation of Therapeutic Dental Polymers to Inhibit Oral Biofilms and Protect Teeth

1
Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100069, China
2
Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA
3
Restorative Dentistry, University Dental School and Hospital, University College Cork, Wilton T12 E8YV, Ireland
4
Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
5
Department of Oral Implantology, School of Dentistry, Jilin University, Changchun 130012, China
6
Department of Operative Dentistry and Endodontics & Stomatology Center, The First Affiliated Medical School of Zhengzhou University, Zhengzhou 450052, China
7
Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
8
University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(9), 1747; https://doi.org/10.3390/ma11091747
Received: 29 August 2018 / Revised: 14 September 2018 / Accepted: 14 September 2018 / Published: 17 September 2018
(This article belongs to the Special Issue Polymeric Materials: Surfaces, Interfaces and Bioapplications)
  |  
PDF [2447 KB, uploaded 19 September 2018]
  |  

Abstract

Polymeric tooth-colored restorations are increasingly popular in dentistry. However, restoration failures remain a major challenge, and more than 50% of all operative work was devoted to removing and replacing the failed restorations. This is a heavy burden, with the expense for restoring dental cavities in the U.S. exceeding $46 billion annually. In addition, the need is increasing dramatically as the population ages with increasing tooth retention in seniors. Traditional materials for cavity restorations are usually bioinert and replace the decayed tooth volumes. This article reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers that not only restore the decayed tooth structures, but also have therapeutic functions. These materials include polymeric composites and bonding agents for tooth cavity restorations that inhibit saliva-based microcosm biofilms, bioactive resins for tooth root caries treatments, polymers that can suppress periodontal pathogens, and root canal sealers that can kill endodontic biofilms. These novel compositions substantially inhibit biofilm growth, greatly reduce acid production and polysaccharide synthesis of biofilms, and reduce biofilm colony-forming units by three to four orders of magnitude. This new class of bioactive and therapeutic polymeric materials is promising to inhibit tooth decay, suppress recurrent caries, control oral biofilms and acid production, protect the periodontium, and heal endodontic infections. View Full-Text
Keywords: polymeric composites; bonding agents; antibacterial; oral biofilms; periodontal pathogens; caries inhibition polymeric composites; bonding agents; antibacterial; oral biofilms; periodontal pathogens; caries inhibition
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Zhang, K.; Baras, B.; Lynch, C.D.; Weir, M.D.; Melo, M.A.S.; Li, Y.; Reynolds, M.A.; Bai, Y.; Wang, L.; Wang, S.; Xu, H.H.K. Developing a New Generation of Therapeutic Dental Polymers to Inhibit Oral Biofilms and Protect Teeth. Materials 2018, 11, 1747.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top