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Open AccessArticle

Hydrogen Peroxide Diffusion through Enamel and Dentin

Department of Stomatology, Universitat de València, Valencia [Spain] C/ Gasco Oliag 1, 46010 Valencia, Spain
Freshage Research Group, Department Physiology, Universitat de València, CIBERFES. INCLIVA. Avda. Blasco Ibáñez, 21, 46010 València, Spain
School of Dentistry, Faculty of Medicine, University of Murcia, Avda. Marques de los Velez s/n, 30008 Murcia, Spain
Author to whom correspondence should be addressed.
Materials 2018, 11(9), 1694;
Received: 17 August 2018 / Revised: 5 September 2018 / Accepted: 9 September 2018 / Published: 12 September 2018
(This article belongs to the Collection Dental Biomaterials)
The purpose of this study was to evaluate the in vitro diffusion of commercial bleaching products (hydrogen peroxide (HP) or carbamide peroxide (CP) based) with different application protocols. Human enamel-dentin discs were obtained and divided into 20 groups. Four commercial products based on HP (Pola Office+(PO), Perfect Bleach (PB), Norblanc Office-automix (NO), and Boost (BT)), and one based on CP (PolaDay CP (PD)), were evaluated with different application protocols (3 applications × 10 min or 1 application × 30 min, with or without light activation). Artificial pulp chambers with 100 µL of a buffer solution were prepared. After each application, the buffer was removed and diffused HP was quantified by fluorimetry. Data were analyzed with two-way analysis of variance (ANOVA) and Tukey’s test. In groups where 3 × 10 min applications were done, after the first 10 min, PB, NO, and PD showed similar diffusion (p < 0.05). After the second and third applications, diffusion proved similar for PO and PD, while PB exhibited the greatest diffusion. In the 30 min application groups, PO and BT showed no significant differences (p > 0.05), with similar results for NO and PD. Comparing products with or without light activation, PO, BT, and PB showed significantly greater diffusion with light activation (p < 0.05). Reapplication, and light activation, increased HP diffusion independently of the concentration of the product. View Full-Text
Keywords: dental bleaching; carbamide peroxide; hydrogen peroxide; diffusion; light activation; application time dental bleaching; carbamide peroxide; hydrogen peroxide; diffusion; light activation; application time
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MDPI and ACS Style

Llena, C.; Martínez-Galdón, O.; Forner, L.; Gimeno-Mallench, L.; Rodríguez-Lozano, F.J.; Gambini, J. Hydrogen Peroxide Diffusion through Enamel and Dentin. Materials 2018, 11, 1694.

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