Next Article in Journal
Research Progress Regarding Interfacial Characteristics and the Strengthening Mechanisms of Titanium Alloy/Hydroxyapatite Composites
Previous Article in Journal
Recent Advances in Scanning Electrochemical Microscopy for Biological Applications
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Materials 2018, 11(8), 1390; https://doi.org/10.3390/ma11081390

Effect of Icariin on Engineered 3D-Printed Porous Scaffolds for Cartilage Repair

1
Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
2
Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, China
*
Authors to whom correspondence should be addressed.
Received: 22 June 2018 / Revised: 2 August 2018 / Accepted: 6 August 2018 / Published: 9 August 2018
Full-Text   |   PDF [6005 KB, uploaded 9 August 2018]   |  

Abstract

In recent times, cartilage defects have been the most common athletic injuries, often leading to dreadful consequences such as osteoarthritis, pain, joint deformities, and other symptoms. It is also evident that damage to articular cartilage is often difficult to recover or self-heal because of poor vascular, nervous, and lymphatic supplies. Moreover, cartilage cells have poor regeneration ability and high maturity. Inspired by these facts and the rapid advances in the field of tissue engineering (TE), we fabricated highly porous three-dimensional (3D) scaffold architectures based on cell-responsive polymeric inks, i.e., sodium alginate and gelatin (SA-Gel, 1:3 ratio), by a novel 3D printing method. Moreover, the effect of various processing parameters was systematically investigated. The printed scaffolds of polymer composites gels with excellent transparency, moderate viscosity, and excellent fluid properties showed good surface morphology, better thermal stability and swelling effect, and unique interconnected porous architectures at the optimized operating parameters. In vitro cell proliferation experiments of these cytocompatible scaffolds showed the excellent adhesion rate and growth behavior of chondrocytes. In addition, the porous architectures facilitated the efficient distribution of cells with only a few remaining on the surface, which was confirmed by confocal laser scanning microscopic (CLSM) observations. Icariin (ICA) addition at a concentration of 10 μg/mL further significantly enhanced the proliferation of chondrocytes. We envision that these cell-responsive polymeric inks in the presence of growth regulators like ICA may have potential in engineering complex tissue constructs toward diverse applications in TE. View Full-Text
Keywords: tissue engineering; 3D printing; icariin; chondrocyte; gelatin; sodium alginate tissue engineering; 3D printing; icariin; chondrocyte; gelatin; sodium alginate
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kankala, R.K.; Lu, F.-J.; Liu, C.-G.; Zhang, S.-S.; Chen, A.-Z.; Wang, S.-B. Effect of Icariin on Engineered 3D-Printed Porous Scaffolds for Cartilage Repair. Materials 2018, 11, 1390.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top