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Surface Modifications of Nanoparticles for Stability in Biological Fluids

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Departamento de Quimica Fisica e Inorganica and EMaS, Universitat Rovira i Virgili Carrer de Marcel•lí Domingo s/n, 43007 Tarragona, Spain
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Institución Catalana de Investigación y Estudios Avanzados, Passeig Lluís Companys 23, 08010 Barcelona, Spain
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Authors to whom correspondence should be addressed.
Materials 2018, 11(7), 1154; https://doi.org/10.3390/ma11071154
Received: 13 June 2018 / Revised: 29 June 2018 / Accepted: 2 July 2018 / Published: 6 July 2018
(This article belongs to the Special Issue Surface Modification of Nanoparticles)
Due to the high surface: volume ratio and the extraordinary properties arising from the nanoscale (optical, electric, magnetic, etc.), nanoparticles (NPs) are excellent candidates for multiple applications. In this context, nanoscience is opening a wide range of modern technologies in biological and biomedical fields, among others. However, one of the main drawbacks that still delays its fast evolution and effectiveness is related to the behavior of nanomaterials in the presence of biological fluids. Unfortunately, biological fluids are characterized by high ionic strengths which usually induce NP aggregation. Besides this problem, the high content in biomacromolecules—such as lipids, sugars, nucleic acids and, especially, proteins—also affects NP stability and its viability for some applications due to, for example, the formation of the protein corona around the NPs. Here, we will review the most common strategies to achieve stable NPs dispersions in high ionic strength fluids and, also, antifouling strategies to avoid the protein adsorption. View Full-Text
Keywords: nanoparticles; biological fluids; colloidal stability; surface modification; protein corona; antifouling; plasmonics; quantum dots; magnetism nanoparticles; biological fluids; colloidal stability; surface modification; protein corona; antifouling; plasmonics; quantum dots; magnetism
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MDPI and ACS Style

Guerrini, L.; Alvarez-Puebla, R.A.; Pazos-Perez, N. Surface Modifications of Nanoparticles for Stability in Biological Fluids. Materials 2018, 11, 1154.

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