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Open AccessArticle

Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization

Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy
Department of Health Sciences, Università del Piemonte Orientale UPO, 28100 Novara, Italy
Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), 28100 Novara, Italy
Research Unit on Implant Infections, Rizzoli Orthopaedic Institute, 40136 Bologna, Italy
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, 40126 Bologna, Italy
Author to whom correspondence should be addressed.
Co-shared authorship.
Materials 2018, 11(6), 961;
Received: 16 April 2018 / Revised: 1 June 2018 / Accepted: 4 June 2018 / Published: 6 June 2018
(This article belongs to the Special Issue State-of-the-Art Materials Science in Italy 2017)
To promote osteointegration and simultaneously limit bacterial contamination without using antibiotics, we designed innovative composite cements containing copper (Cu)-doped bioactive glass powders. Cu-doped glass powders were produced by a melt and quenching process, followed by an ion-exchange process in a Cu salt aqueous solution. Cu-doped glass was incorporated into commercial polymethyl methacrylate (PMMA)-based cements with different viscosities. The realized composites were characterized in terms of morphology, composition, leaching ability, bioactivity, mechanical, and antibacterial properties. Glass powders appeared well distributed and exposed on the PMMA surface. Composite cements showed good bioactivity, evidencing hydroxyapatite precipitation on the sample surfaces after seven days of immersion in simulated body fluid. The leaching test demonstrated that composite cements released a significant amount of copper, with a noticeable antibacterial effect toward Staphylococcus epidermidis strain. Thus, the proposed materials represent an innovative and multifunctional tool for orthopedic prostheses fixation, temporary prostheses, and spinal surgery. View Full-Text
Keywords: copper; bioactive glass; antimicrobial; composite bone cement copper; bioactive glass; antimicrobial; composite bone cement
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Miola, M.; Cochis, A.; Kumar, A.; Arciola, C.R.; Rimondini, L.; Verné, E. Copper-Doped Bioactive Glass as Filler for PMMA-Based Bone Cements: Morphological, Mechanical, Reactivity, and Preliminary Antibacterial Characterization. Materials 2018, 11, 961.

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