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Open AccessArticle

Novel Calcium Zirconate Silicate Cement Biomineralize and Seal Root Canals

1
Department of Conservative Dentistry, Kyung Hee University Dental Hospital, Kyung Hee University School of Dentistry, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
2
Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital & Seoul Dental Hospital for Disabled, Seoul National University School of Dentistry, 101 Daehak-ro, Jongro-gu, Seoul 03080, Korea
3
Schulich School of Medicine & Dentistry, University of Western Ontario, 1151 Richmond Street, London, ON N6A3K7, Canada
4
Department of Materials Science and Engineering, Seoul National University, 1 Kwanak-ro, Kwanak-gu, Seoul 08826, Korea
5
U Dental Hospital, 175 Dasan-ro, Jung-gu, Seoul 04608, Korea
*
Author to whom correspondence should be addressed.
The first two authors contributed equally to this work.
Materials 2018, 11(4), 588; https://doi.org/10.3390/ma11040588
Received: 11 March 2018 / Revised: 4 April 2018 / Accepted: 10 April 2018 / Published: 11 April 2018
(This article belongs to the Section Biomaterials)
This study evaluated the sealing ability of gutta-percha (GP) with a calcium silicate-based sealer and a novel calcium zirconate containing calcium silicate cement (ZC). The root canals of the extracted premolars were prepared, which were then randomly allocated to three experimental groups (12 root canals per group) for obturation by continuous wave of condensation with the GP and AH 26 sealer (CW); obturation using a single GP with a calcium silicate-based EndoSequence BC sealer (SC); or obturation with ZC. The roots were inserted into sterile Eppendorf tubes, which were inoculated coronally with Porphyromonas gingivalis. The amount of endotoxin leakage into the apical reservoirs were measured using the Limulus Amebocyte Lysate (LAL) assay over 21 days, with comparisons made using one-way ANOVA and Scheffe’s tests (α = 0.05). After 21 days, 75% of the canals that had been obturated by SC, 50% of those obturated by CW and 42% of those obturated by ZC showed endotoxin leakage. The amount of leakage was higher in the SC canals than in the CW (p = 0.031) or ZC (p = 0.03) canals, although there was no significant difference in the amount of leakage for CW and ZC (p > 0.05). X-ray diffraction revealed the presence of tricalcium silicate (Ca3SiO5) and calcium zirconate (CaZrO3) in the synthesized ZC. Scanning electron microscopy revealed mineralized precipitates on the dentin of canals obturated by ZC. The novel calcium zirconate silicate cement appears to promote biomineralization and seal root canals at least as effectively as the conventional sealer. View Full-Text
Keywords: calcium silicate-based sealer; endotoxin leakage; scanning electron microscopy; sealing ability; calcium zirconate silicate cement calcium silicate-based sealer; endotoxin leakage; scanning electron microscopy; sealing ability; calcium zirconate silicate cement
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Oh, S.; Cho, S.-I.; Perinpanayagam, H.; You, J.; Hong, S.-H.; Yoo, Y.-J.; Chang, S.W.; Shon, W.-J.; Yoo, J.-S.; Baek, S.-H.; Kum, K.-Y. Novel Calcium Zirconate Silicate Cement Biomineralize and Seal Root Canals. Materials 2018, 11, 588.

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