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Open AccessArticle

MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

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Polymer Materials Research Department, Advanced Technologies and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934 Alexandria, Egypt
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Laboratory of Bioorganic Chemistry of Drugs, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 84104 Bratislava, Slovakia
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School of Engineering, Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
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Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934 Alexandria, Egypt
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Chemistry Department, Faculty of Science, University of Jeddah, Osfan, P. O. Box: 80203, 21589 Jeddah, Saudi Arabia
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Department of Toxicology and Laboratory Animals Breeding, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 91954 Dobra Voda 360, Slovakia
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National Agricultural and Food Centre, Research Institute for Animal Production Nitra, Department of Small Farm Animals, 951 41 Lužianky, Slovakia
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St. Elizabeth Cancer Institute Hospital, Department of Pathology, Bratislava, 84104, Slovakia
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Department of Chemical Sciences, Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
*
Author to whom correspondence should be addressed.
Materials 2018, 11(4), 569; https://doi.org/10.3390/ma11040569
Received: 16 February 2018 / Revised: 3 April 2018 / Accepted: 4 April 2018 / Published: 7 April 2018
(This article belongs to the Section Biomaterials)
Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant—MitoQ—was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods. The results showed that the prepared thrombogenic Ch/HA/MitoQ membranes had higher roughness, which allowed for greater surface area for tissue membrane interaction during the healing processes, and lower cytotoxicity levels than controls. MitoQ-loaded composite membranes displayed superior healing properties in these animal models compared to control membranes. View Full-Text
Keywords: mitochondrially-targeted antioxidant; skin wounds; hyaluronan; chitosan mitochondrially-targeted antioxidant; skin wounds; hyaluronan; chitosan
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MDPI and ACS Style

Tamer, T.M.; Collins, M.N.; Valachová, K.; Hassan, M.A.; Omer, A.M.; Mohy-Eldin, M.S.; Švík, K.; Jurčík, R.; Ondruška, Ľ.; Biró, C.; Albadarin, A.B.; Šoltés, L. MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing. Materials 2018, 11, 569.

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