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Open AccessFeature PaperArticle

Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum

1
Institute for Microelectronics and Microsystems—Unit of Naples—National Council of Research, Via Pietro Castellino, 80131 Naples, Italy
2
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Napoli, Italy
3
Department of Movement Sciences and Wellbeing, University of Naples “Parthenope”, Via Medina 40, 80133 Napoli, Italy
4
Lawrence Berkeley National Laboratory, Molecular Foundry Division, 67 Cyclotron Road, Berkeley, CA 94720, USA
*
Author to whom correspondence should be addressed.
Materials 2018, 11(4), 526; https://doi.org/10.3390/ma11040526
Received: 2 March 2018 / Revised: 27 March 2018 / Accepted: 28 March 2018 / Published: 30 March 2018
(This article belongs to the Special Issue Photonic Crystals for Chemical Sensing and Biosensing)
A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excellent interrogation stability and loss-free operation, requires minimal optical interrogation equipment and can be easily optimized to work in a wide wavelength range. View Full-Text
Keywords: photonic crystal; bound states in the continuum; biosensors; protein interaction photonic crystal; bound states in the continuum; biosensors; protein interaction
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MDPI and ACS Style

Romano, S.; Lamberti, A.; Masullo, M.; Penzo, E.; Cabrini, S.; Rendina, I.; Mocella, V. Optical Biosensors Based on Photonic Crystals Supporting Bound States in the Continuum. Materials 2018, 11, 526.

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