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3D Printability of Alginate-Carboxymethyl Cellulose Hydrogel

1
Industrial and Manufacturing Engineering Department, North Dakota State University, Fargo, ND 58102, USA
2
Pharmaceutical Sciences Department, North Dakota State University, Fargo, ND 58102, USA
*
Author to whom correspondence should be addressed.
Materials 2018, 11(3), 454; https://doi.org/10.3390/ma11030454
Received: 3 February 2018 / Revised: 7 March 2018 / Accepted: 8 March 2018 / Published: 20 March 2018
(This article belongs to the Special Issue NextGen Materials for 3D Printing)
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Abstract

Three-dimensional (3D) bio-printing is a revolutionary technology to reproduce a 3D functional living tissue scaffold in-vitro through controlled layer-by-layer deposition of biomaterials along with high precision positioning of cells. Due to its bio-compatibility, natural hydrogels are commonly considered as the scaffold material. However, the mechanical integrity of a hydrogel material, especially in 3D scaffold architecture, is an issue. In this research, a novel hybrid hydrogel, that is, sodium alginate with carboxymethyl cellulose (CMC) is developed and systematic quantitative characterization tests are conducted to validate its printability, shape fidelity and cell viability. The outcome of the rheological and mechanical test, filament collapse and fusion test demonstrate the favorable shape fidelity. Three-dimensional scaffold structures are fabricated with the pancreatic cancer cell, BxPC3 and the 86% cell viability is recorded after 23 days. This hybrid hydrogel can be a potential biomaterial in 3D bioprinting process and the outlined characterization techniques open an avenue directing reproducible printability and shape fidelity. View Full-Text
Keywords: shape fidelity; bio-printing; hybrid hydrogel shape fidelity; bio-printing; hybrid hydrogel
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Habib, A.; Sathish, V.; Mallik, S.; Khoda, B. 3D Printability of Alginate-Carboxymethyl Cellulose Hydrogel. Materials 2018, 11, 454.

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