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Modelling and Optimization of Polycaprolactone Ultrafine-Fibres Electrospinning Process Using Response Surface Methodology

School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia
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Materials 2018, 11(3), 441; https://doi.org/10.3390/ma11030441
Received: 19 February 2018 / Revised: 9 March 2018 / Accepted: 11 March 2018 / Published: 17 March 2018
Electrospun fibres have gained broad interest in biomedical applications, including tissue engineering scaffolds, due to their potential in mimicking extracellular matrix and producing structures favourable for cell and tissue growth. The development of scaffolds often involves multivariate production parameters and multiple output characteristics to define product quality. In this study on electrospinning of polycaprolactone (PCL), response surface methodology (RSM) was applied to investigate the determining parameters and find optimal settings to achieve the desired properties of fibrous scaffold for acetabular labrum implant. The results showed that solution concentration influenced fibre diameter, while elastic modulus was determined by solution concentration, flow rate, temperature, collector rotation speed, and interaction between concentration and temperature. Relationships between these variables and outputs were modelled, followed by an optimization procedure. Using the optimized setting (solution concentration of 10% w/v, flow rate of 4.5 mL/h, temperature of 45 °C, and collector rotation speed of 1500 RPM), a target elastic modulus of 25 MPa could be achieved at a minimum possible fibre diameter (1.39 ± 0.20 µm). This work demonstrated that multivariate factors of production parameters and multiple responses can be investigated, modelled, and optimized using RSM. View Full-Text
Keywords: electrospinning; polycaprolactone; response surface methodology; fibre diameter; elastic modulus electrospinning; polycaprolactone; response surface methodology; fibre diameter; elastic modulus
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Anindyajati, A.; Boughton, P.; Ruys, A.J. Modelling and Optimization of Polycaprolactone Ultrafine-Fibres Electrospinning Process Using Response Surface Methodology. Materials 2018, 11, 441.

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