Highly Sensitive and Selective Potassium Ion Detection Based on Graphene Hall Effect Biosensors
AbstractPotassium (K+) ion is an important biological substance in the human body and plays a critical role in the maintenance of transmembrane potential and hormone secretion. Several detection techniques, including fluorescent, electrochemical, and electrical methods, have been extensively investigated to selectively recognize K+ ions. In this work, a highly sensitive and selective biosensor based on single-layer graphene has been developed for K+ ion detection under Van der Pauw measurement configuration. With pre-immobilization of guanine-rich DNA on the graphene surface, the graphene devices exhibit a very low limit of detection (≈1 nM) with a dynamic range of 1 nM–10 μM and excellent K+ ion specificity against other alkali cations, such as Na+ ions. The origin of K+ ion selectivity can be attributed to the fact that the formation of guanine-quadruplexes from guanine-rich DNA has a strong affinity for capturing K+ ions. The graphene-based biosensors with improved sensing performance for K+ ion recognition can be applied to health monitoring and early disease diagnosis. View Full-Text
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Liu, X.; Ye, C.; Li, X.; Cui, N.; Wu, T.; Du, S.; Wei, Q.; Fu, L.; Yin, J.; Lin, C.-T. Highly Sensitive and Selective Potassium Ion Detection Based on Graphene Hall Effect Biosensors. Materials 2018, 11, 399.
Liu X, Ye C, Li X, Cui N, Wu T, Du S, Wei Q, Fu L, Yin J, Lin C-T. Highly Sensitive and Selective Potassium Ion Detection Based on Graphene Hall Effect Biosensors. Materials. 2018; 11(3):399.Chicago/Turabian Style
Liu, Xiangqi; Ye, Chen; Li, Xiaoqing; Cui, Naiyuan; Wu, Tianzhun; Du, Shiyu; Wei, Qiuping; Fu, Li; Yin, Jiancheng; Lin, Cheng-Te. 2018. "Highly Sensitive and Selective Potassium Ion Detection Based on Graphene Hall Effect Biosensors." Materials 11, no. 3: 399.
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