Electrospun F18 Bioactive Glass/PCL—Poly (ε-caprolactone)—Membrane for Guided Tissue Regeneration
by
Lucas Hidalgo Pitaluga 1,*, Marina Trevelin Souza 1, Edgar Dutra Zanotto 1
, Martin Eduardo Santocildes Romero 2 and Paul V. Hatton 2
Lucas Hidalgo Pitaluga 1,*, Marina Trevelin Souza 1, Edgar Dutra Zanotto 1, Martin Eduardo Santocildes Romero 2 and Paul V. Hatton 2
1
CeRTEV—Center for Research, Technology and Education in Vitreous Materials, Department of Materials Engineering, Federal University of São Carlos, 13565-905 São Carlos, Brazil
2
School of Clinical Dentistry, The University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK
*
Author to whom correspondence should be addressed.
Materials 2018, 11(3), 400; https://doi.org/10.3390/ma11030400
Received: 30 January 2018 / Revised: 26 February 2018 / Accepted: 2 March 2018 / Published: 8 March 2018
(This article belongs to the Special Issue Bioactive Glasses 2017)
Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly (ε-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively. The PCL-F18 composite membranes demonstrated no increased cytotoxicity and an enhanced osteogenic potential when compared to pure PCL membranes. Moreover, the addition of the bioactive phase increased the membrane tensile strength. These preliminary results suggested that these new membranes can be a strong candidate for small bone injuries treatment by GTR technique.
View Full-Text
Keywords:
membranes; guided tissue regeneration; tissue engineering; electrospinning; bone regeneration; bioactive glass
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Hidalgo Pitaluga, L.; Trevelin Souza, M.; Dutra Zanotto, E.; Santocildes Romero, M.E.; Hatton, P.V. Electrospun F18 Bioactive Glass/PCL—Poly (ε-caprolactone)—Membrane for Guided Tissue Regeneration. Materials 2018, 11, 400.
Show more citation formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
