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Open AccessArticle

Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)

1
Dpto. Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain
2
Centro Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28040 Madrid, Spain
3
Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy
*
Authors to whom correspondence should be addressed.
Materials 2018, 11(3), 367; https://doi.org/10.3390/ma11030367
Received: 30 January 2018 / Revised: 26 February 2018 / Accepted: 27 February 2018 / Published: 2 March 2018
(This article belongs to the Special Issue Selected papers from EUROMAT 2017 Conference—Biomaterials)
Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications. View Full-Text
Keywords: gallium ions; mesoporous glasses; glass structure; in vitro bioactivity; antibacterial capability gallium ions; mesoporous glasses; glass structure; in vitro bioactivity; antibacterial capability
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Sanchez-Salcedo, S.; Malavasi, G.; Salinas, A.J.; Lusvardi, G.; Rigamonti, L.; Menabue, L.; Vallet-Regi, M. Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III). Materials 2018, 11, 367.

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