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Open AccessArticle

Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)

Dpto. Química en Ciencias Farmacéuticas, Instituto de Investigación Sanitaria Hospital 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain
Centro Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28040 Madrid, Spain
Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125 Modena, Italy
Authors to whom correspondence should be addressed.
Materials 2018, 11(3), 367;
Received: 30 January 2018 / Revised: 26 February 2018 / Accepted: 27 February 2018 / Published: 2 March 2018
(This article belongs to the Special Issue Selected papers from EUROMAT 2017 Conference—Biomaterials)
Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications. View Full-Text
Keywords: gallium ions; mesoporous glasses; glass structure; in vitro bioactivity; antibacterial capability gallium ions; mesoporous glasses; glass structure; in vitro bioactivity; antibacterial capability
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Sanchez-Salcedo, S.; Malavasi, G.; Salinas, A.J.; Lusvardi, G.; Rigamonti, L.; Menabue, L.; Vallet-Regi, M. Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III). Materials 2018, 11, 367.

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