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Nanoparticle-Based Strategies to Treat Neuro-Inflammation

INSERM, U1043, CNRS, U5282, Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse-Purpan, F-31300 Toulouse, France
Author to whom correspondence should be addressed.
Materials 2018, 11(2), 270;
Received: 29 December 2017 / Revised: 2 February 2018 / Accepted: 6 February 2018 / Published: 9 February 2018
(This article belongs to the Special Issue Nanomaterials for Biomedical Applications)
Neuro-inflammation is a pivotal physio-pathological feature of brain disorders, including neurodegenerative diseases. As such, it is a relevant therapeutic target against which drugs have to be proposed. Targeting neuro-inflammation implies crossing the Blood-Brain Barrier (BBB) to reach the Central Nervous System (CNS). Engineered nanoparticles (ENPs) are promising candidates to carry and deliver drugs to the CNS by crossing the BBB. There are several strategies to design ENPs intended for crossing through the BBB. Herein, we first put nanotechnologies back in their historical context and introduce neuro-inflammation and its consequences in terms of public health. In a second part, we explain how ENPs can get access to the brain and review this area by highlighting recent papers in the field. Finally, after pointing out potential guidelines for preclinical studies involving ENPs, we conclude by opening the debate on the questions of nanosafety and toxicity of these ENPs and in particular on ecotoxicity related to regulatory issues and public concerns. View Full-Text
Keywords: nanotechnology; nanoparticles; neuro-inflammation; blood-brain barrier; nanosafety nanotechnology; nanoparticles; neuro-inflammation; blood-brain barrier; nanosafety
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Poupot, R.; Bergozza, D.; Fruchon, S. Nanoparticle-Based Strategies to Treat Neuro-Inflammation. Materials 2018, 11, 270.

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