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Materials 2018, 11(12), 2492; https://doi.org/10.3390/ma11122492

A Novel Class of Injectable Bioceramics That Glue Tissues and Biomaterials

1
Applied Material Science, Department of Engineering, Uppsala University, 75121 Uppsala, Sweden
2
Department of Materials and Environmental Chemistry, Stockholm University, 10691 Stockholm, Sweden
3
Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden
4
Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK
5
Department of Biomaterials, Institute of Clinical Sciences, University of Gothenburg, 40530 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 30 November 2018 / Accepted: 3 December 2018 / Published: 7 December 2018
(This article belongs to the Section Biomaterials)
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Abstract

Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5–4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids. View Full-Text
Keywords: cement; tissue adhesive; phosphoserine; self-assembly; amorphous calcium phosphate (ACP); correlation nuclear magnetic resonance (NMR) spectroscopy; bioinspired; biomaterial cement; tissue adhesive; phosphoserine; self-assembly; amorphous calcium phosphate (ACP); correlation nuclear magnetic resonance (NMR) spectroscopy; bioinspired; biomaterial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pujari-Palmer, M.; Guo, H.; Wenner, D.; Autefage, H.; Spicer, C.D.; Stevens, M.M.; Omar, O.; Thomsen, P.; Edén, M.; Insley, G.; Procter, P.; Engqvist, H. A Novel Class of Injectable Bioceramics That Glue Tissues and Biomaterials. Materials 2018, 11, 2492.

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