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Materials 2017, 10(7), 740;

In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass

Department of Pathology and Molecular Pharmacology, IByME-CONICET, C1428ADN Buenos Aires, Argentina
Department of Developmental Biology, National University of Salta, A4408FVY Salta, Argentina
Institute of Experimental Pathology, IPE-CONICET, A4408FVY Salta, Argentina
Research Institute for Materials Science and Technology, INTEMA-CONICET, B7608FDQ Mar del Plata, Argentina
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
Interdisciplinary Materials Group-IESIING-UCASAL, INTECIN UBA-CONICET, A4400EDD Salta, Argentina
Both authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 1 June 2017 / Revised: 24 June 2017 / Accepted: 29 June 2017 / Published: 3 July 2017
(This article belongs to the Special Issue Bioactive Glasses 2017)
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Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from a base 45S5 BG composition containing (wt %) 45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O5, in which Na2O was partially substituted by 5% Li2O (45S5.5Li), were obtained. The results demonstrate that human umbilical vein endothelial cells (HUVECs) have greater migratory and proliferative response and ability to form tubules in vitro after stimulation with the ionic dissolution products (IDPs) of the 45S5.5Li BG. The results also show the activation of the canonical Wnt/β-catenin pathway and the increase in expression of proangiogenic cytokines insulin like growth factor 1 (IGF1) and transforming growth factor beta (TGFβ). We conclude that the IDPs of 45S5.5Li BG would act as useful inorganic agents to improve tissue repair and regeneration, ultimately stimulating HUVECs behavior in the absence of exogenous growth factors. View Full-Text
Keywords: endothelial cell; lithium; bioactive glass endothelial cell; lithium; bioactive glass

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Haro Durand, L.A.; Vargas, G.E.; Vera-Mesones, R.; Baldi, A.; Zago, M.P.; Fanovich, M.A.; Boccaccini, A.R.; Gorustovich, A. In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass. Materials 2017, 10, 740.

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