Performance of a New Al2O3/Ce–TZP Ceramic Nanocomposite Dental Implant: A Pilot Study in Dogs.
Abstract
:1. Introduction
2. Materials and Methods
2.1. Powder Processing and Microstructural Characterization
2.2. Characterization of the Alumina/Ce-TZP Nanocomposite
2.2.1. Mechanical Properties of Alumina/Ce-TZP Material
2.2.2. Determination of Surface Topography (Discs and Implants)
2.3. Determination of the In Vitro Response
2.3.1. Cell Immunostaining and Imaging
2.3.2. In Vitro Cytotoxicity
2.3.3. In Vitro Osseous Differentiation Determination
2.4. In Vivo Test
2.4.1. Animals
2.4.2. Surgery
2.4.3. Histological Preparation and Analysis
3. Results and Discussion
3.1. Nanocomposite Characterization
3.2. In Vitro Biological Assays
3.3. Histological Descriptive Interpretation of Thin Ground Preparations.
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Material | Supplier | Designation | Purity | d50 (nm) | Specific Surface |
---|---|---|---|---|---|
Al2O3 | Sasol | SPA 0.5 | >99.9% | 380 | 7.7 m2/g |
ZrO2 10% CeO2 | Daiichi Kigenso | 10 Ce-TZP | >99.9% | 35 | 14.3 m2/g |
Parameter | Ra 1 (µm) | Ra 2 (µm) | Ra 3 (µm) | Avg. Ra (µm) | Ra S.D. (µm) | Overall Avg. Ra (µm) | Overall Ra S.D. (µm) |
---|---|---|---|---|---|---|---|
Peak 1 | 1.58 | 1.09 | 1.32 | 1.33 | 0.25 | 1.38 | 0.24 |
Peak 2 | 1.72 | 1.20 | 1.36 | 1.43 | 0.27 | ||
Peak 3 | 1.47 | 1.16 | 1.54 | 1.39 | 0.20 | ||
Valley 1 | 0.94 | 0.92 | 0.83 | 0.90 | 0.06 | 0.93 | 0.10 |
Valley 2 | 0.88 | 0.83 | 0.83 | 0.85 | 0.03 | ||
Valley 3 | 0.92 | 0.94 | 1.32 | 1.06 | 0.23 |
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Lopez-Píriz, R.; Fernández, A.; Goyos-Ball, L.; Rivera, S.; Díaz, L.A.; Fernández-Domínguez, M.; Prado, C.; Moya, J.S.; Torrecillas, R. Performance of a New Al2O3/Ce–TZP Ceramic Nanocomposite Dental Implant: A Pilot Study in Dogs. Materials 2017, 10, 614. https://doi.org/10.3390/ma10060614
Lopez-Píriz R, Fernández A, Goyos-Ball L, Rivera S, Díaz LA, Fernández-Domínguez M, Prado C, Moya JS, Torrecillas R. Performance of a New Al2O3/Ce–TZP Ceramic Nanocomposite Dental Implant: A Pilot Study in Dogs. Materials. 2017; 10(6):614. https://doi.org/10.3390/ma10060614
Chicago/Turabian StyleLopez-Píriz, Roberto, Adolfo Fernández, Lidia Goyos-Ball, Sergio Rivera, Luis A. Díaz, Manuel Fernández-Domínguez, Catuxa Prado, José S. Moya, and Ramón Torrecillas. 2017. "Performance of a New Al2O3/Ce–TZP Ceramic Nanocomposite Dental Implant: A Pilot Study in Dogs." Materials 10, no. 6: 614. https://doi.org/10.3390/ma10060614
APA StyleLopez-Píriz, R., Fernández, A., Goyos-Ball, L., Rivera, S., Díaz, L. A., Fernández-Domínguez, M., Prado, C., Moya, J. S., & Torrecillas, R. (2017). Performance of a New Al2O3/Ce–TZP Ceramic Nanocomposite Dental Implant: A Pilot Study in Dogs. Materials, 10(6), 614. https://doi.org/10.3390/ma10060614