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Comparative Efficacies of Collagen-Based 3D Printed PCL/PLGA/β-TCP Composite Block Bone Grafts and Biphasic Calcium Phosphate Bone Substitute for Bone Regeneration

1
Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea
2
Department of Mechanical System Engineering, Graduate School of Knowledge-Based Technology and Energy, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do 15073, Korea
3
Department of Plastic and Reconstructive Surgery, Kyungpook National University, School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea
4
Department of Mechanical Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do 15073, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Georgios E. Romanos
Materials 2017, 10(4), 421; https://doi.org/10.3390/ma10040421
Received: 13 February 2017 / Revised: 4 April 2017 / Accepted: 14 April 2017 / Published: 17 April 2017
The purpose of this study was to compare bone regeneration and space maintaining ability of three-dimensional (3D) printed bone grafts with conventional biphasic calcium phosphate (BCP). After mixing polycaprolactone (PCL), poly (lactic-co-glycolic acid) (PLGA), and β-tricalcium phosphate (β-TCP) in a 4:4:2 ratio, PCL/PLGA/β-TCP particulate bone grafts were fabricated using 3D printing technology. Fabricated particulate bone grafts were mixed with atelocollagen to produce collagen-based PCL/PLGA/β-TCP composite block bone grafts. After formation of calvarial defects 8 mm in diameter, PCL/PLGA/β-TCP composite block bone grafts and BCP were implanted into bone defects of 32 rats. Although PCL/PLGA/β-TCP composite block bone grafts were not superior in bone regeneration ability compared to BCP, the results showed relatively similar performance. Furthermore, PCL/PLGA/β-TCP composite block bone grafts showed better ability to maintain bone defects and to support barrier membranes than BCP. Therefore, within the limitations of this study, PCL/PLGA/β-TCP composite block bone grafts could be considered as an alternative to synthetic bone grafts available for clinical use. View Full-Text
Keywords: PCL/PLGA/β-TCP; 3D printing; collagen; bone grafts; BCP PCL/PLGA/β-TCP; 3D printing; collagen; bone grafts; BCP
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Hwang, K.-S.; Choi, J.-W.; Kim, J.-H.; Chung, H.Y.; Jin, S.; Shim, J.-H.; Yun, W.-S.; Jeong, C.-M.; Huh, J.-B. Comparative Efficacies of Collagen-Based 3D Printed PCL/PLGA/β-TCP Composite Block Bone Grafts and Biphasic Calcium Phosphate Bone Substitute for Bone Regeneration. Materials 2017, 10, 421.

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