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Materials 2017, 10(3), 320;

The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration

Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS, School of Dentistry, Pusan National University, Yangsan 50612, Korea
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeollabuk-do 56212, Korea
Author to whom correspondence should be addressed.
Received: 13 February 2017 / Revised: 14 March 2017 / Accepted: 17 March 2017 / Published: 21 March 2017
(This article belongs to the Section Biomaterials)
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This study introduces the effect of the thickness of a bacterial cellulose membrane by comparing the bone regeneration effect on rat skulls when using a collagen membrane and different thicknesses of resorbable bacterial cellulose membranes for guided bone regeneration. Barrier membranes of 0.10 mm, 0.15 mm, and 0.20 mm in thickness were made using bacterial cellulose produced as microbial fermentation metabolites. Mechanical strength was investigated, and new bone formation was evaluated through animal experimental studies. Experimental animals were sacrificed after having 2 weeks and 8 weeks of recovery, and specimens were processed for histologic and histomorphometric analyses measuring the area of bone regeneration (%) using an image analysis program. In 2 weeks, bone-like materials and fibrous connective tissues were observed in histologic analysis. In 8 weeks, all experimental groups showed the arrangement of osteoblasts surrounding the supporting body on the margin and center of the bone defect region. However, the amount of new bone formation was significantly higher (p < 0.05) in bacterial cellulose membrane with 0.10 mm in thickness compared to the other experimental groups. Within the limitations of this study, a bacterial cellulose membrane with 0.10 mm thickness induced the most effective bone regeneration. View Full-Text
Keywords: bacterial cellulose; guided bone regeneration; membrane; resorbable membrane, thickness bacterial cellulose; guided bone regeneration; membrane; resorbable membrane, thickness

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Lee, Y.-J.; An, S.-J.; Bae, E.-B.; Gwon, H.-J.; Park, J.-S.; Jeong, S.I.; Jeon, Y.-C.; Lee, S.-H.; Lim, Y.-M.; Huh, J.-B. The Effect of Thickness of Resorbable Bacterial Cellulose Membrane on Guided Bone Regeneration. Materials 2017, 10, 320.

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