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Advances in the Fabrication of Antimicrobial Hydrogels for Biomedical Applications

Departamento de Química, Matemáticas y del Medio Ambiente, Facultad de Ciencias Naturales, Universidad Tecnológica Metropolitana, P.O. Box 9845, Correo 21, Santiago 7800003, Chile
Departamento de Ingeniería Estructural y Geotecnia, Escuela de Ingeniería, Pontificia Universidad Católica de Chile, P.O. Box 306, Correo 22, Santiago 7820436, Chile
Departamento de Química y Propiedades de Polímeros, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC), Juan de la Cierva 3, Madrid 28006, Spain
Author to whom correspondence should be addressed.
Academic Editors: Jie Zheng, Yuping Bao and John Zhanhu Guo
Materials 2017, 10(3), 232;
Received: 3 January 2017 / Revised: 7 February 2017 / Accepted: 20 February 2017 / Published: 26 February 2017
(This article belongs to the Special Issue Smart Biomaterials and Biointerfaces)
PDF [8165 KB, uploaded 27 February 2017]


This review describes, in an organized manner, the recent developments in the elaboration of hydrogels that possess antimicrobial activity. The fabrication of antibacterial hydrogels for biomedical applications that permits cell adhesion and proliferation still remains as an interesting challenge, in particular for tissue engineering applications. In this context, a large number of studies has been carried out in the design of hydrogels that serve as support for antimicrobial agents (nanoparticles, antibiotics, etc.). Another interesting approach is to use polymers with inherent antimicrobial activity provided by functional groups contained in their structures, such as quaternary ammonium salt or hydrogels fabricated from antimicrobial peptides (AMPs) or natural polymers, such as chitosan. A summary of the different alternatives employed for this purpose is described in this review, considering their advantages and disadvantages. Finally, more recent methodologies that lead to more sophisticated hydrogels that are able to react to external stimuli are equally depicted in this review. View Full-Text
Keywords: hydrogels; antimicrobial activity; antimicrobial agents; chitosan; silver nanoparticles hydrogels; antimicrobial activity; antimicrobial agents; chitosan; silver nanoparticles

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González-Henríquez, C.M.; Sarabia-Vallejos, M.A.; Rodriguez-Hernandez, J. Advances in the Fabrication of Antimicrobial Hydrogels for Biomedical Applications. Materials 2017, 10, 232.

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