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Aspects of Solvent Chemistry for Calcium Hydroxide Medicaments

Private dental practice, Annerley, QLD 4013, Australia
School of Dentistry, University of Queensland, Herston, Brisbane, QLD 4004, Australia
Author to whom correspondence should be addressed.
Materials 2017, 10(10), 1219;
Received: 13 September 2017 / Revised: 17 October 2017 / Accepted: 17 October 2017 / Published: 23 October 2017
(This article belongs to the Special Issue Dental Biomaterials 2017)
PDF [421 KB, uploaded 24 October 2017]


Calcium hydroxide pastes have been used in endodontics since 1947. Most current calcium hydroxide endodontic pastes use water as the vehicle, which limits the dissolution of calcium hydroxide that can be achieved and, thereby, the maximum pH that can be achieved within the root canal system. Using polyethylene glycol as a solvent, rather than water, can achieve an increase in hydroxyl ions release compared to water or saline. By adopting non-aqueous solvents such as the polyethylene glycols (PEG), greater dissolution and faster hydroxyl ion release can be achieved, leading to enhanced antimicrobial actions, and other improvements in performance and biocompatibility. View Full-Text
Keywords: endodontics; medicaments; calcium hydroxide; polyethylene glycol; alkalinity; disinfection endodontics; medicaments; calcium hydroxide; polyethylene glycol; alkalinity; disinfection

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Athanassiadis, B.; Walsh, L.J. Aspects of Solvent Chemistry for Calcium Hydroxide Medicaments. Materials 2017, 10, 1219.

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