Next Article in Journal
In Situ TEM Multi-Beam Ion Irradiation as a Technique for Elucidating Synergistic Radiation Effects
Next Article in Special Issue
Comparison of the Percentage of Voids in the Canal Filling of a Calcium Silicate-Based Sealer and Gutta Percha Cones Using Two Obturation Techniques
Previous Article in Journal
The Influence of Water Sorption of Dental Light-Cured Composites on Shrinkage Stress
Previous Article in Special Issue
The Efficacy of Electron Beam Irradiated Bacterial Cellulose Membranes as Compared with Collagen Membranes on Guided Bone Regeneration in Peri-Implant Bone Defects
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview

Alkaline Sodium Hypochlorite Irrigant and Its Chemical Interactions

The University of Queensland School of Dentistry, Brisbane 4006, Australia
Author to whom correspondence should be addressed.
Materials 2017, 10(10), 1147;
Received: 5 September 2017 / Revised: 23 September 2017 / Accepted: 24 September 2017 / Published: 29 September 2017
(This article belongs to the Special Issue Dental Biomaterials 2017)
PDF [221 KB, uploaded 29 September 2017]


Endodontic irrigating solutions may interact chemically with one another. This is important, because even when solutions are not admixed, they will come into contact with one another during an alternating irrigation technique, forming unwanted by-products, which may be toxic or irritant. Mixing or alternating irrigants can also reduce their ability to clean and disinfect the root canal system of teeth by changing their chemical structure with subsequent loss of the active agent, or by inducing precipitate formation in the root canal system. Precipitates occlude dental tubules, resulting in less penetration of antimicrobials and a loss of disinfection efficacy. Sodium hypochlorite is not only a very reactive oxidizing agent, but is also the most commonly used endodontic irrigant. As such, many interactions occurring between it and other irrigants, chelators and other antimicrobials, may occur. Of particular interest is the interaction between sodium hypochlorite and the chelators EDTA, citric acid and etidronate and between sodium hypochlorite and the antimicrobials chlorhexidine, alexidine, MTAD and octenisept. View Full-Text
Keywords: endodontic irrigant interactions; clinical implications; sodium hypochlorite; EDTA; citric acid; etidronate; chlorhexidine; MTAD; alexidine; octenisept endodontic irrigant interactions; clinical implications; sodium hypochlorite; EDTA; citric acid; etidronate; chlorhexidine; MTAD; alexidine; octenisept
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wright, P.P.; Kahler, B.; Walsh, L.J. Alkaline Sodium Hypochlorite Irrigant and Its Chemical Interactions. Materials 2017, 10, 1147.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top