Alkaline Sodium Hypochlorite Irrigant and Its Chemical Interactions
Abstract
:1. Introduction
2. Reactions of Sodium Hypochlorite with Chelating Agents
2.1. Reactions of Sodium Hypochlorite with Ethylenediaminetetraacetic Acid
2.1.1. Chemistry
2.1.2. Clinical Implications
2.2. Reactions of Sodium Hypochlorite and Citric Acid
2.2.1. Chemistry
2.2.2. Clinical Implications
2.3. Reactions of Sodium Hypochlorite with Etidronate
2.3.1. Chemistry
2.3.2. Clinical Implications
3. Reactions of NaOCl with Antimicrobial Agents or Antimicrobial/Chelator Mixtures
3.1. Reactions of Sodium Hypochlorite with Chlorhexidine
3.1.1. Chemistry
3.1.2. Clinical Implications
3.2. Reactions of Sodium Hypochlorite with Alexidine
3.2.1. Chemistry
3.2.2. Clinical Implications
3.3. Reactions of Sodium Hypochlorite with MTAD
3.3.1. Chemistry
3.3.2. Clinical Implications
3.4. Reactions of Sodium Hypochlorite with Octenisept
3.4.1. Chemistry
3.4.2. Clinical Implications
4. Conclusions
Acknowledgments
Conflicts of Interest
References
- Dakin, H.D. On the use of certain antiseptic substances in the treatment of infected wounds. Br. Med. J. 1915, 2, 318–320. [Google Scholar] [CrossRef] [PubMed]
- Walker, A. A definite and dependable therapy for pulpless teeth. J. Am. Dent. Assoc. 1936, 23, 1418–1425. [Google Scholar]
- Haapasalo, M.; Shen, Y.; Wang, Z.; Gao, Y. Irrigation in endodontics. Br. Dent. J. 2014, 216, 299–303. [Google Scholar] [CrossRef] [PubMed]
- Shen, Y.; Gao, Y.; Lin, J.; Ma, J.; Wang, Z.; Haapasalo, M. Methods and models to study irrigation. Endod. Top. 2012, 27, 3–34. [Google Scholar] [CrossRef]
- Wayman, B.E.; Kopp, W.M.; Pinero, G.J.; Lazzari, E. Citric and lactic acids as root canal irrigants in vitro. J. Endod. 1979, 5, 258–265. [Google Scholar] [CrossRef]
- Haapasalo, M.; Shen, Y.; Qian, W.; Gao, Y. Irrigation in endodontics. Dent. Clin. N. Am. 2010, 54, 291–312. [Google Scholar] [CrossRef] [PubMed]
- Zehnder, M.; Schmidlin, P.; Sener, B.; Waltimo, T. Chelation in root canal therapy reconsidered. J. Endod. 2005, 31, 817–820. [Google Scholar] [CrossRef] [PubMed]
- Ruiz-Linares, M.; Aguado-Pérez, B.; Baca, P.; Arias-Moliz, M.; Ferrer-Luque, C. Efficacy of antimicrobial solutions against polymicrobial root canal biofilm. Int. Endod. J. 2017, 50, 77–83. [Google Scholar] [CrossRef] [PubMed]
- Krishnan, U.; Saji, S.; Clarkson, R.; Lalloo, R.; Moule, A.J. Free active chlorine in sodium hypochlorite solutions admixed with octenidine, smearoff, chlorhexidine, and EDTA. J. Endod. 2017, 43, 1354–1359. [Google Scholar] [CrossRef] [PubMed]
- Zehnder, M. Root canal irrigants. J. Endod. 2006, 32, 389–398. [Google Scholar] [CrossRef] [PubMed]
- Tay, F.R.; Hiraishi, N.; Schuster, G.S.; Pashley, D.H.; Loushine, R.J.; Ounsi, H.F.; Grandini, S.; Yau, J.Y.; Mazzoni, A.; Donnelly, A.; et al. Reduction in antimicrobial substantivity of MTAD after initial sodium hypochlorite irrigation. J. Endod. 2006, 32, 970–975. [Google Scholar] [CrossRef] [PubMed]
- Clarkson, R.; Moule, A.; Podlich, H.; Kellaway, R.; Macfarlane, R.; Lewis, D.; Rowell, J. Dissolution of porcine incisor pulps in sodium hypochlorite solutions of varying compositions and concentrations. Aust. Dent. J. 2006, 51, 245–251. [Google Scholar] [CrossRef] [PubMed]
- Cárdenas-Bahena, Á.; Sánchez-García, S.; Tinajero-Morales, C.; González-Rodríguez, V.M.; Baires-Várguez, L. Use of sodium hypochlorite in root canal irrigation. Opinion survey and concentration in commercial products. Rev. Odontol. Mex. 2012, 16, 252–258. [Google Scholar]
- Fukuzaki, S. Mechanisms of actions of sodium hypochlorite in cleaning and disinfection processes. Biocontrol Sci. 2006, 11, 147–157. [Google Scholar] [CrossRef] [PubMed]
- Del Carpio-Perochena, A.; Bramante, C.M.; de Andrade, F.B.; Maliza, A.G.A.; Cavenago, B.C.; Marciano, M.A.; Amoroso-Silva, P.; Duarte, M.H. Antibacterial and dissolution ability of sodium hypochlorite in different pHs on multi-species biofilms. Clin. Oral Investig. 2015, 19, 2067–2073. [Google Scholar] [CrossRef] [PubMed]
- Tartari, T.; Oda, D.; Zancan, R.; Silva, T.; Moraes, I.; Duarte, M.; Bramante, C. Mixture of alkaline tetrasodium EDTA with sodium hypochlorite promotes in vitro smear layer removal and organic matter dissolution during biomechanical preparation. Int. Endod. J. 2017, 50, 106–114. [Google Scholar] [CrossRef] [PubMed]
- Arias-Moliz, M.T.; Morago, A.; Ordinola-Zapata, R.; Ferrer-Luque, C.M.; Ruiz-Linares, M.; Baca, P. Effects of dentin debris on the antimicrobial properties of sodium hypochlorite and etidronic acid. J. Endod. 2016, 42, 771–775. [Google Scholar] [CrossRef] [PubMed]
- Vanysek, P. Electrochemical series. In CRC Handbook of Chemistry and Physics, 91st ed.; Haynes, W., Ed.; CRC Press: Boca Raton, FL, USA, 2010. [Google Scholar]
- Nowicki, J.B.; Sem, D.S. An in vitro spectroscopic analysis to determine the chemical composition of the precipitate formed by mixing sodium hypochlorite and chlorhexidine. J. Endod. 2011, 37, 983–988. [Google Scholar] [CrossRef] [PubMed]
- Baumgartner, J.C.; Ibay, A.C. The chemical reactions of irrigants used for root canal debridement. J. Endod. 1987, 13, 47–51. [Google Scholar] [CrossRef]
- Clarkson, R.M.; Podlich, H.M.; Moule, A.J. Influence of ethylenediaminetetraacetic acid on the active chlorine content of sodium hypochlorite solutions when mixed in various proportions. J. Endod. 2011, 37, 538–543. [Google Scholar] [CrossRef] [PubMed]
- Grawehr, M.; Sener, B.; Waltimo, T.; Zehnder, M. Interactions of ethylenediamine tetraacetic acid with sodium hypochlorite in aqueous solutions. Int. Endod. J. 2003, 36, 411–415. [Google Scholar] [CrossRef] [PubMed]
- Prado, M.; Júnior, H.M.S.; Rezende, C.M.; Pinto, A.C.; Faria, R.B.; Simão, R.A.; Gomes, B.P. Interactions between irrigants commonly used in endodontic practice: A chemical analysis. J. Endod. 2013, 39, 505–510. [Google Scholar] [CrossRef] [PubMed]
- Grande, N.M.; Plotino, G.; Falanga, A.; Pomponi, M.; Somma, F. Interaction between EDTA and sodium hypochlorite: A nuclear magnetic resonance analysis. J. Endod. 2006, 32, 460–464. [Google Scholar] [CrossRef] [PubMed]
- Biel, P.; Mohn, D.; Attin, T.; Zehnder, M. Interactions between the tetrasodium salts of EDTA and 1-hydroxyethane 1, 1-diphosphonic acid with sodium hypochlorite irrigants. J. Endod. 2017, 43, 657–661. [Google Scholar] [CrossRef] [PubMed]
- De Almeida, L.H.S.; Gomes, A.P.N.; Souza, E.M.; Pappen, F.G. Influence of EDTA and dentine in tissue dissolution ability of sodium hypochlorite. Aust. Endod. J. 2015, 41, 7–11. [Google Scholar] [CrossRef] [PubMed]
- Tokuda, M.; Kawakami, Y.; Morimoto-Yamashita, Y.; Torii, M. Subcutaneous emphysema caused by sodium hypochlorite plus RC-prep. Open J. Stom. 2014, 4, 527. [Google Scholar] [CrossRef]
- Guerreiro-Tanomaru, J.M.; Morgental, R.D.; Flumignan, D.L.; Gasparini, F.; Oliveira, J.E.; Tanomaru-Filho, M. Evaluation of pH, available chlorine content, and antibacterial activity of endodontic irrigants and their combinations against Enterococcus faecalis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2011, 112, 132–135. [Google Scholar] [CrossRef] [PubMed]
- Tartari, T.; Guimaraes, B.M.; Amoras, L.S.; Duarte, M.A.; Silva e Souza, P.A.; Bramante, C.M. Etidronate causes minimal changes in the ability of sodium hypochlorite to dissolve organic matter. Int. Endod. J. 2015, 48, 399–404. [Google Scholar] [CrossRef] [PubMed]
- Lottanti, S.; Gautschi, H.; Sener, B.; Zehnder, M. Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the smear layer. Int. Endod. J. 2009, 42, 335–343. [Google Scholar] [CrossRef] [PubMed]
- Arias-Moliz, M.T.; Ordinola-Zapata, R.; Baca, P.; Ruiz-Linares, M.; Ferrer-Luque, C.M. Antimicrobial activity of a sodium hypochlorite/etidronic acid irrigant solution. J. Endod. 2014, 40, 1999–2002. [Google Scholar] [CrossRef] [PubMed]
- Russell, A.; Day, M. Antibacterial activity of chlorhexidine. J. Hosp. Infect. 1993, 25, 229–238. [Google Scholar] [CrossRef]
- Tanzer, J.; Slee, A.; Kamay, B. Structural requirements of guanide, biguanide, and bisbiguanide agents for antiplaque activity. Antimicrob. Agents Chemother. 1977, 12, 721–729. [Google Scholar] [CrossRef] [PubMed]
- Basrani, B.R.; Manek, S.; Sodhi, R.N.; Fillery, E.; Manzur, A. Interaction between sodium hypochlorite and chlorhexidine gluconate. J. Endod. 2007, 33, 966–969. [Google Scholar] [CrossRef] [PubMed]
- Krishnamurthy, S.; Sudhakaran, S. Evaluation and prevention of the precipitate formed on interaction between sodium hypochlorite and chlorhexidine. J. Endod. 2010, 36, 1154–1157. [Google Scholar] [CrossRef] [PubMed]
- Kolosowski, K.P.; Sodhi, R.N.; Kishen, A.; Basrani, B.R. Qualitative analysis of precipitate formation on the surface and in the tubules of dentin irrigated with sodium hypochlorite and a final rinse of chlorhexidine or QMiX. J. Endod. 2014, 40, 2036–2040. [Google Scholar] [CrossRef] [PubMed]
- Mortenson, D.; Sadilek, M.; Flake, N.M.; Paranjpe, A.; Heling, I.; Johnson, J.D.; Cohenca, N. The effect of using an alternative irrigant between sodium hypochlorite and chlorhexidine to prevent the formation of para-chloroaniline within the root canal system. Int. Endod. J. 2012, 45, 878–882. [Google Scholar] [CrossRef] [PubMed]
- Thomas, J.E.; Sem, D.S. An in vitro spectroscopic analysis to determine whether para-chloroaniline is produced from mixing sodium hypochlorite and chlorhexidine. J. Endod. 2010, 36, 315–317. [Google Scholar] [CrossRef] [PubMed]
- Orhan, E.O.; Irmak, Ö.; Hür, D.; Yaman, B.C.; Karabucak, B. Does para-chloroaniline really form after mixing sodium hypochlorite and chlorhexidine? J. Endod. 2016, 42, 455–459. [Google Scholar] [CrossRef] [PubMed]
- Basrani, B.; Santos, J.M.; Tjäderhane, L.; Grad, H.; Gorduysus, O.; Huang, J.; Lawrence, H.P.; Friedman, S. Substantive antimicrobial activity in chlorhexidine-treated human root dentin. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2002, 94, 240–245. [Google Scholar] [CrossRef] [PubMed]
- Bui, T.B.; Baumgartner, J.C.; Mitchell, J.C. Evaluation of the interaction between sodium hypochlorite and chlorhexidine gluconate and its effect on root dentin. J. Endod. 2008, 34, 181–185. [Google Scholar] [CrossRef] [PubMed]
- Gasic, J.; Popovic, J.; Živković, S.; Petrovic, A.; Barac, R.; Nikolic, M. Ultrastructural analysis of the root canal walls after simultaneous irrigation of different sodium hypochlorite concentration and 0.2% chlorhexidine gluconate. Microsc. Res. Tech. 2012, 75, 1099–1103. [Google Scholar] [CrossRef] [PubMed]
- Akisue, E.; Tomita, V.S.; Gavini, G.; de Figueiredo, J.A.P. Effect of the combination of sodium hypochlorite and chlorhexidine on dentinal permeability and scanning electron microscopy precipitate observation. J. Endod. 2010, 36, 847–850. [Google Scholar] [CrossRef] [PubMed]
- Kim, H.S.; Zhu, Q.; Baek, S.H.; Jung, I.Y.; Son, W.J.; Chang, S.W.; Lee, W.; Gu, Y.; Lee, Y.; Hong, S.T.; et al. Chemical interaction of alexidine and sodium hypochlorite. J. Endod. 2012, 38, 112–116. [Google Scholar] [CrossRef] [PubMed]
- Tong, Z.; Ling, J.; Lin, Z.; Li, X.; Mu, Y. The effect of MTADN on 10 Enterococcus faecalis isolates and biofilm: An in vitro study. J. Endod. 2013, 39, 674–678. [Google Scholar] [CrossRef] [PubMed]
- Caswell, A.; Hutchison, J. Selectivity of cation chelation to tetracyclines: Evidence for special conformation of calcium chelate. Biochem. Biophys. Res. Commun. 1971, 43, 625–630. [Google Scholar] [CrossRef]
- Tay, F.R.; Mazzoni, A.; Pashley, D.H.; Day, T.E.; Ngoh, E.C.; Breschi, L. Potential iatrogenic tetracycline staining of endodontically treated teeth via NaOCl/MTAD irrigation: A preliminary report. J. Endod. 2006, 32, 354–358. [Google Scholar] [CrossRef] [PubMed]
- Thaha, K.A.; Varma, R.L.; Nair, M.G.; Joseph, V.S.; Krishnan, U. Interaction between octenidine-based solution and sodium hypochlorite: A mass spectroscopy, proton nuclear magnetic resonance, and scanning electron microscopy–based observational study. J. Endod. 2017, 43, 135–140. [Google Scholar] [CrossRef] [PubMed]
- Bailey, D.M.; DeGrazia, C.G.; Hoff, S.J.; Schulenberg, P.L.; O’Connor, J.R.; Paris, D.A.; Slee, A.M. Bispyridinamines: A new class of topical antimicrobial agents as inhibitors of dental plaque. J. Med. Chem. 1984, 27, 1457–1464. [Google Scholar] [CrossRef] [PubMed]
- Tirali, R.E.; Turan, Y.; Akal, N.; Karahan, Z.C. In vitro antimicrobial activity of several concentrations of NaOCl and Octenisept in elimination of endodontic pathogens. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2009, 108, e117–e120. [Google Scholar] [CrossRef] [PubMed]
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Wright, P.P.; Kahler, B.; Walsh, L.J. Alkaline Sodium Hypochlorite Irrigant and Its Chemical Interactions. Materials 2017, 10, 1147. https://doi.org/10.3390/ma10101147
Wright PP, Kahler B, Walsh LJ. Alkaline Sodium Hypochlorite Irrigant and Its Chemical Interactions. Materials. 2017; 10(10):1147. https://doi.org/10.3390/ma10101147
Chicago/Turabian StyleWright, Patricia P., Bill Kahler, and Laurence J. Walsh. 2017. "Alkaline Sodium Hypochlorite Irrigant and Its Chemical Interactions" Materials 10, no. 10: 1147. https://doi.org/10.3390/ma10101147
APA StyleWright, P. P., Kahler, B., & Walsh, L. J. (2017). Alkaline Sodium Hypochlorite Irrigant and Its Chemical Interactions. Materials, 10(10), 1147. https://doi.org/10.3390/ma10101147