Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies
Abstract
:1. Introduction
2. Results and Discussion
2.1. CH-PEO/HA membrane characterization
2.2. Cell viability
2.3. Paclitaxel Release from CH-PEO/HA membranes
Sample | K | a | R2 |
---|---|---|---|
0.60 mg Pac | 0.19 | -0.07 | 0.9959 |
0.51 mg Pac | 0.25 | -0.09 | 0.9956 |
0.24 mg Pac | 0.48 | -0.21 | 0.9959 |
Sample | K | a | R2 |
---|---|---|---|
8.0 mg spheres | 0.08 | -0.056 | 0.9881 |
9.5 mg spheres | 0.09 | -0.060 | 0.9941 |
2.4. Thrombogenecity
3. Experimental Section
3.1. Preparation of hyaluronan (HA) ester prodrug of paclitaxel (Pac)
3.2. CH-PEO membrane formation
3.3. Membrane-covered stent preparation
3.4. Self-assembled monolayer coatings: membrane-HA and membrane HA-Pac preparation
3.5. Membrane assessment during inflation
3.6. Preparation of microspheres
3.7. SEM analysis
3.8. Determination of drug loading
3.9. Drug activity assessment by cell viability studies
3.10. Drug release studies
3.10.1. Drug release study from CH-PEO/HA/Pac membranes
3.10.2. Drug release study from CH-PEO/HA + Pac membranes
3.10.3. Drug release study from CH-PEO/HA + PLGA membranes
3.11. Isolation and labelling of platelets
3.12. Statistics
4. Conclusions
Acknowledgements
References and Notes
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Sydow-Plum, G.; Haidar, Z.S.; Merhi, Y.; Tabrizian, M. Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies. Materials 2008, 1, 25-43. https://doi.org/10.3390/ma1010025
Sydow-Plum G, Haidar ZS, Merhi Y, Tabrizian M. Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies. Materials. 2008; 1(1):25-43. https://doi.org/10.3390/ma1010025
Chicago/Turabian StyleSydow-Plum, Georg, Ziyad S. Haidar, Yahye Merhi, and Maryam Tabrizian. 2008. "Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies" Materials 1, no. 1: 25-43. https://doi.org/10.3390/ma1010025